UCK2 (uridine-cytidine kinase 2)

2007-02-01  

Identity

HGNC
UCK2
LOCATION
1q24.1
LOCUSID
7371
ALIAS
TSA903,UK,UMPK
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 7371
MIM: 609329
HGNC: 12562
Ensembl: ENSG00000143179

Variants:

dbSNP: 7371
ClinVar: 7371
TCGA: ENSG00000143179
COSMIC: UCK2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000143179ENST00000367879Q9BZX2
ENSG00000143179ENST00000367879A0A024R912
ENSG00000143179ENST00000469256Q9BZX2
ENSG00000143179ENST00000470820Q9BZX2
ENSG00000143179ENST00000642653A0A2R8Y653

Expression (GTEx)

0
5
10
15
20
25
30
35
40
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Pyrimidine metabolismKEGGko00240
Drug metabolism - other enzymesKEGGko00983
Pyrimidine metabolismKEGGhsa00240
Drug metabolism - other enzymesKEGGhsa00983
Metabolic pathwaysKEGGhsa01100
MetabolismREACTOMER-HSA-1430728
Metabolism of nucleotidesREACTOMER-HSA-15869
Pyrimidine metabolismREACTOMER-HSA-73848
Pyrimidine salvage reactionsREACTOMER-HSA-73614

References

Pubmed IDYearTitleCitations
195361752009Follow-up of a major linkage peak on chromosome 1 reveals suggestive QTLs associated with essential hypertension: GenNet study.30
234622922013Testicular germ cell tumor susceptibility associated with the UCK2 locus on chromosome 1q23.30
190646102009Pre-B-cell leukemia homeobox 1 (PBX1) shows functional and possible genetic association with bone mineral density variation.16
176135362007Tiling resolution array comparative genomic hybridization, expression and methylation analyses of dup(1q) in Burkitt lymphomas and pediatric high hyperdiploid acute lymphoblastic leukemias reveal clustered near-centromeric breakpoints and overexpression of genes in 1q22-32.3.12
152802202004A crucial role of uridine/cytidine kinase 2 in antitumor activity of 3'-ethynyl nucleosides.10
121999062002Epstein-Barr virus encoded nuclear protein EBNA-3 binds a novel human uridine kinase/uracil phosphoribosyltransferase.7
312788862019Uridine-cytidine kinase 2 (UCK2): A potential diagnostic and prognostic biomarker for lung cancer.5
305566102019Uridine-cytidine kinase 2 upregulation predicts poor prognosis of hepatocellular carcinoma and is associated with cancer aggressiveness.4
303045692019UCK2 upregulation might serve as an indicator of unfavorable prognosis of hepatocellular carcinoma.3
195329872009Quantum mechanics/molecular mechanics investigation of the mechanism of phosphate transfer in human uridine-cytidine kinase 2.2

Citation

Dessen P

UCK2 (uridine-cytidine kinase 2)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46207/uck2