UCMA (upper zone of growth plate and cartilage matrix associated)

2014-11-01  

Identity

HGNC
UCMA
LOCATION
10p13
LOCUSID
221044
ALIAS
C10orf49,GRP,GRP/UCMA

Other Information

Locus ID:

NCBI: 221044
HGNC: 25205
Ensembl: ENSG00000165623

Variants:

dbSNP: 221044
ClinVar: 221044
TCGA: ENSG00000165623
COSMIC: UCMA

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000165623ENST00000378681Q8WVF2
ENSG00000165623ENST00000378681A0A067XJX6
ENSG00000165623ENST00000463405R4GMV7

Expression (GTEx)

0
1
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
N/A

References

Pubmed IDYearTitleCitations
293017902018Chronic Kidney Disease Circulating Calciprotein Particles and Extracellular Vesicles Promote Vascular Calcification: A Role for GRP (Gla-Rich Protein).33
181561822008Ucma, a novel secreted cartilage-specific protein with implications in osteogenesis.23
188361832008Gla-rich protein (GRP), a new vitamin K-dependent protein identified from sturgeon cartilage and highly conserved in vertebrates.21
177076222008Ucma--A novel secreted factor represents a highly specific marker for distal chondrocytes.20
285424102017Gla-rich protein function as an anti-inflammatory agent in monocytes/macrophages: Implications for calcification-related chronic inflammatory diseases.17
263374792016Gla-rich protein is involved in the cross-talk between calcification and inflammation in osteoarthritis.16
248672942014Insights into the association of Gla-rich protein and osteoarthritis, novel splice variants and γ-carboxylation status.9
244096762013Exon resequencing of the gene encoding UCma/GRP reveals a common carboxy-terminal 138Thr > Ser polymorphism.0

Citation

Dessen P

UCMA (upper zone of growth plate and cartilage matrix associated)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/75457/ucma