UGDH (UDP-glucose 6-dehydrogenase)

2010-02-01  

Identity

HGNC
LOCATION
4p14
LOCUSID
ALIAS
DEE84,EIEE84,GDH,UDP-GlcDH,UDPGDH,UGD
FUSION GENES

Other Information

Locus ID:

NCBI: 7358
MIM: 603370
HGNC: 12525
Ensembl: ENSG00000109814

Variants:

dbSNP: 7358
ClinVar: 7358
TCGA: ENSG00000109814
COSMIC: UGDH

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000109814ENST00000316423O60701
ENSG00000109814ENST00000501493O60701
ENSG00000109814ENST00000503779E9PBD2
ENSG00000109814ENST00000505698E7ER95
ENSG00000109814ENST00000506179O60701
ENSG00000109814ENST00000507089O60701
ENSG00000109814ENST00000509391E7ER83
ENSG00000109814ENST00000510490D6RHF4
ENSG00000109814ENST00000510881E9PBD2
ENSG00000109814ENST00000514106E7ETF4
ENSG00000109814ENST00000515021E7EV97

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90

Pathways

PathwaySourceExternal ID
Pentose and glucuronate interconversionsKEGGko00040
Ascorbate and aldarate metabolismKEGGko00053
Amino sugar and nucleotide sugar metabolismKEGGko00520
Pentose and glucuronate interconversionsKEGGhsa00040
Ascorbate and aldarate metabolismKEGGhsa00053
Amino sugar and nucleotide sugar metabolismKEGGhsa00520
Metabolic pathwaysKEGGhsa01100
Nucleotide sugar biosynthesis, eukaryotesKEGGhsa_M00361
Glucuronate pathway (uronate pathway)KEGGM00014
Nucleotide sugar biosynthesis, eukaryotesKEGGM00361
Glucuronate pathway (uronate pathway)KEGGhsa_M00014
MetabolismREACTOMER-HSA-1430728
Biological oxidationsREACTOMER-HSA-211859
Phase II conjugationREACTOMER-HSA-156580
GlucuronidationREACTOMER-HSA-156588
Formation of the active cofactor, UDP-glucuronateREACTOMER-HSA-173599

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
204214872010Genome-wide association identifies candidate genes that influence the human electroencephalogram.37
215023152011Structure and mechanism of human UDP-glucose 6-dehydrogenase.28
304206062018The entropic force generated by intrinsically disordered segments tunes protein function.22
215762482011Divergent Sp1 protein levels may underlie differential expression of UDP-glucose dehydrogenase by fibroblasts: role in susceptibility to orbital Graves disease.17
150444862004Characterization of human UDP-glucose dehydrogenase. CYS-276 is required for the second of two successive oxidations.16
215954452011Role of packing defects in the evolution of allostery and induced fit in human UDP-glucose dehydrogenase.15
196760542010Udp-glucose dehydrogenase as a novel field-specific candidate biomarker of prostate cancer.13
233632392013Hysteresis and negative cooperativity in human UDP-glucose dehydrogenase.12
172095472007Characterization of human UDP-glucose dehydrogenase reveals critical catalytic roles for lysine 220 and aspartate 280.11
219615652011Conformational flexibility in the allosteric regulation of human UDP-α-D-glucose 6-dehydrogenase.10

Citation

Dessen P

UGDH (UDP-glucose 6-dehydrogenase)

Atlas Genet Cytogenet Oncol Haematol. 2010-02-01

Online version: http://atlasgeneticsoncology.org/gene/51337/ugdh