UGDH (UDP-glucose 6-dehydrogenase)

2010-02-01  

Identity

HGNC
UGDH
LOCATION
4p14
LOCUSID
7358
ALIAS
DEE84,EIEE84,GDH,UDP-GlcDH,UDPGDH,UGD
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 7358
MIM: 603370
HGNC: 12525
Ensembl: ENSG00000109814

Variants:

dbSNP: 7358
ClinVar: 7358
TCGA: ENSG00000109814
COSMIC: UGDH

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000109814ENST00000316423O60701
ENSG00000109814ENST00000501493O60701
ENSG00000109814ENST00000503779E9PBD2
ENSG00000109814ENST00000505698E7ER95
ENSG00000109814ENST00000506179O60701
ENSG00000109814ENST00000507089O60701
ENSG00000109814ENST00000509391E7ER83
ENSG00000109814ENST00000510490D6RHF4
ENSG00000109814ENST00000510881E9PBD2
ENSG00000109814ENST00000514106E7ETF4
ENSG00000109814ENST00000515021E7EV97

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Pentose and glucuronate interconversionsKEGGko00040
Ascorbate and aldarate metabolismKEGGko00053
Amino sugar and nucleotide sugar metabolismKEGGko00520
Pentose and glucuronate interconversionsKEGGhsa00040
Ascorbate and aldarate metabolismKEGGhsa00053
Amino sugar and nucleotide sugar metabolismKEGGhsa00520
Metabolic pathwaysKEGGhsa01100
Nucleotide sugar biosynthesis, eukaryotesKEGGhsa_M00361
Glucuronate pathway (uronate pathway)KEGGM00014
Nucleotide sugar biosynthesis, eukaryotesKEGGM00361
Glucuronate pathway (uronate pathway)KEGGhsa_M00014
MetabolismREACTOMER-HSA-1430728
Biological oxidationsREACTOMER-HSA-211859
Phase II conjugationREACTOMER-HSA-156580
GlucuronidationREACTOMER-HSA-156588
Formation of the active cofactor, UDP-glucuronateREACTOMER-HSA-173599

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
375939992023Phenotypic and genetic characteristics of 24 cases of early infantile epileptic encephalopathy in East China, including a rare case of biallelic UGDH mutations.1
378581592023UGDH promotes tumor-initiating cells and a fibroinflammatory tumor microenvironment in ovarian cancer.2
375939992023Phenotypic and genetic characteristics of 24 cases of early infantile epileptic encephalopathy in East China, including a rare case of biallelic UGDH mutations.1
378581592023UGDH promotes tumor-initiating cells and a fibroinflammatory tumor microenvironment in ovarian cancer.2
356178082022UDP-glucose 6-dehydrogenase lessens sorafenib sensitivity via modulating unfolded protein response.2
356178082022UDP-glucose 6-dehydrogenase lessens sorafenib sensitivity via modulating unfolded protein response.2
327499012021Integration of Sugar Metabolism and Proteoglycan Synthesis by UDP-glucose Dehydrogenase.16
327499012021Integration of Sugar Metabolism and Proteoglycan Synthesis by UDP-glucose Dehydrogenase.16
313084902020UDP-glucose 6-dehydrogenase regulates hyaluronic acid production and promotes breast cancer progression.30
320017162020Loss-of-function mutations in UDP-Glucose 6-Dehydrogenase cause recessive developmental epileptic encephalopathy.26
327685252020UDP-glucose 6-dehydrogenase knockout impairs migration and decreases in vivo metastatic ability of breast cancer cells.17
328939772020Targeting UDP-glucose dehydrogenase inhibits ovarian cancer growth and metastasis.10
313084902020UDP-glucose 6-dehydrogenase regulates hyaluronic acid production and promotes breast cancer progression.30
320017162020Loss-of-function mutations in UDP-Glucose 6-Dehydrogenase cause recessive developmental epileptic encephalopathy.26
327685252020UDP-glucose 6-dehydrogenase knockout impairs migration and decreases in vivo metastatic ability of breast cancer cells.17

Citation

Dessen P

UGDH (UDP-glucose 6-dehydrogenase)

Atlas Genet Cytogenet Oncol Haematol. 2010-02-01

Online version: http://atlasgeneticsoncology.org/gene/51337/ugdh