UGP2 (UDP-glucose pyrophosphorylase 2)

2014-08-01  

Identity

HGNC
LOCATION
2p15
LOCUSID
ALIAS
DEE83,EIEE83,SVUGP2,UDPG,UDPGP,UDPGP2,UGP1,UGPP1,UGPP2,pHC379
FUSION GENES

Other Information

Locus ID:

NCBI: 7360
MIM: 191760
HGNC: 12527
Ensembl: ENSG00000169764

Variants:

dbSNP: 7360
ClinVar: 7360
TCGA: ENSG00000169764
COSMIC: UGP2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000169764ENST00000337130Q16851
ENSG00000169764ENST00000394417Q16851
ENSG00000169764ENST00000394417A0A140VKE1
ENSG00000169764ENST00000445915E7EUC7
ENSG00000169764ENST00000466642F8WC70
ENSG00000169764ENST00000467400F2Z3H1
ENSG00000169764ENST00000467648Q16851
ENSG00000169764ENST00000467648A0A140VKE1
ENSG00000169764ENST00000467999H7C500
ENSG00000169764ENST00000472047C9JWG0
ENSG00000169764ENST00000475462C9JVG3
ENSG00000169764ENST00000480679C9J3M0
ENSG00000169764ENST00000482668C9JTZ5
ENSG00000169764ENST00000483108F2Z3P4
ENSG00000169764ENST00000484142C9J6Q0
ENSG00000169764ENST00000487042F8WC70
ENSG00000169764ENST00000487640F8WC70
ENSG00000169764ENST00000488245C9JUW1
ENSG00000169764ENST00000491621C9JNZ1
ENSG00000169764ENST00000493222F2Z3P4
ENSG00000169764ENST00000496334F8WDA2
ENSG00000169764ENST00000497510F2Z3H1
ENSG00000169764ENST00000497883C9JQU9
ENSG00000169764ENST00000613823A0A087WYS1
ENSG00000169764ENST00000626380F8WC70
ENSG00000169764ENST00000627474F2Z3P4
ENSG00000169764ENST00000640075F2Z3H1

Expression (GTEx)

0
50
100
150
200
250

Pathways

PathwaySourceExternal ID
Pentose and glucuronate interconversionsKEGGko00040
Galactose metabolismKEGGko00052
Starch and sucrose metabolismKEGGko00500
Amino sugar and nucleotide sugar metabolismKEGGko00520
Pentose and glucuronate interconversionsKEGGhsa00040
Galactose metabolismKEGGhsa00052
Starch and sucrose metabolismKEGGhsa00500
Amino sugar and nucleotide sugar metabolismKEGGhsa00520
Metabolic pathwaysKEGGhsa01100
Nucleotide sugar biosynthesis, eukaryotesKEGGhsa_M00361
Nucleotide sugar biosynthesis, eukaryotesKEGGM00361
Nucleotide sugar biosynthesis, glucose => UDP-glucoseKEGGhsa_M00549
Nucleotide sugar biosynthesis, glucose => UDP-glucoseKEGGM00549
MetabolismREACTOMER-HSA-1430728
Metabolism of carbohydratesREACTOMER-HSA-71387
Glucose metabolismREACTOMER-HSA-70326
Glycogen synthesisREACTOMER-HSA-3322077
Biological oxidationsREACTOMER-HSA-211859
Phase II conjugationREACTOMER-HSA-156580
GlucuronidationREACTOMER-HSA-156588
Formation of the active cofactor, UDP-glucuronateREACTOMER-HSA-173599

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
203001972010Hypoxia promotes glycogen accumulation through hypoxia inducible factor (HIF)-mediated induction of glycogen synthase 1.67
221328582012The crystal structure of human UDP-glucose pyrophosphorylase reveals a latch effect that influences enzymatic activity.9
232549952013Octamerization is essential for enzymatic function of human UDP-glucose pyrophosphorylase.7
293479442018Expression of UGP2 and CFL1 expression levels in benign and malignant pancreatic lesions and their clinicopathological significance.6
205148522009Variants of organic anion transporter polypeptide 2 gene are not risk factors associated with severe neonatal hyperbilirubinemia.0

Citation

Dessen P

UGP2 (UDP-glucose pyrophosphorylase 2)

Atlas Genet Cytogenet Oncol Haematol. 2014-08-01

Online version: http://atlasgeneticsoncology.org/gene/54750/ugp2