UGT1A10 (UDP glucuronosyltransferase family 1 member A10)

2007-02-01 Affiliation

Identity

HGNC

UGT1A10

LOCATION

2q37.1

LOCUSID

54575

ALIAS

GNT1,UDPGT,UGT-1A,UGT-1J,UGT1,UGT1-01,UGT1-10,UGT1.1,UGT1.10,UGT1A,UGT1A1,UGT1J,hUG-BR1

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 54575
MIM: 606435
HGNC: 12531
Ensembl: ENSG00000242515

Variants:

dbSNP: 54575
ClinVar: 54575
TCGA: ENSG00000242515
COSMIC: UGT1A10

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000242515	ENST00000344644	Q9HAW8
ENSG00000242515	ENST00000344644	Q5DT02
ENSG00000242515	ENST00000373445	Q9HAW8

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Pentose and glucuronate interconversions	KEGG	ko00040
Ascorbate and aldarate metabolism	KEGG	ko00053
Steroid hormone biosynthesis	KEGG	ko00140
Retinol metabolism	KEGG	ko00830
Porphyrin and chlorophyll metabolism	KEGG	ko00860
Metabolism of xenobiotics by cytochrome P450	KEGG	ko00980
Drug metabolism - cytochrome P450	KEGG	ko00982
Drug metabolism - other enzymes	KEGG	ko00983
Pentose and glucuronate interconversions	KEGG	hsa00040
Ascorbate and aldarate metabolism	KEGG	hsa00053
Steroid hormone biosynthesis	KEGG	hsa00140
Retinol metabolism	KEGG	hsa00830
Porphyrin and chlorophyll metabolism	KEGG	hsa00860
Metabolism of xenobiotics by cytochrome P450	KEGG	hsa00980
Drug metabolism - cytochrome P450	KEGG	hsa00982
Drug metabolism - other enzymes	KEGG	hsa00983
Metabolic pathways	KEGG	hsa01100
Glucuronate pathway (uronate pathway)	KEGG	M00014
Chemical carcinogenesis	KEGG	hsa05204
Chemical carcinogenesis	KEGG	ko05204
Glucuronate pathway (uronate pathway)	KEGG	hsa_M00014

PharmGKB

Entity ID	Name	Type	Evidence	Association	PK	PD	PMIDs
PA164748728	mycophenolic acid	Chemical	Pathway	associated			24220207
PA165110775	SN-38	Chemical	Pathway	associated
PA165958521	febuxostat	Chemical	ClinicalAnnotation	associated		PD	27798726
PA420	UGT1A1	Gene	VipGene	associated			15179404, 18004212, 18491077, 18518849, 19794410, 19997083, 8467709, 11434514
PA444065	Epilepsy	Disease	ClinicalAnnotation	associated	PK	PD	15761113, 21806385, 27900402, 28763744
PA444318	Gout	Disease	ClinicalAnnotation	associated		PD	27798726
PA445601	Osteosarcoma	Disease	ClinicalAnnotation	associated	PK		29791011
PA445629	Seizures	Disease	ClinicalAnnotation	associated		PD	27900402
PA447216	Schizophrenia	Disease	ClinicalAnnotation	associated		PD
PA448320	allopurinol	Chemical	ClinicalAnnotation	associated		PD	27798726
PA450428	methotrexate	Chemical	ClinicalAnnotation	associated	PK		29791011
PA450732	oxcarbazepine	Chemical	ClinicalAnnotation	associated		PD	27900402
PA451257	risperidone	Chemical	ClinicalAnnotation	associated		PD
PA451846	valproic acid	Chemical	ClinicalAnnotation, VariantAnnotation	associated	PK	PD	15761113, 21806385, 28763744

References

Pubmed ID	Year	Title	Citations
19913121	2009	Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.	85
19898482	2009	Genetic variants in TPMT and COMT are associated with hearing loss in children receiving cisplatin chemotherapy.	84
17558305	2007	Irinotecan pharmacokinetics/pharmacodynamics and UGT1A genetic polymorphisms in Japanese: roles of UGT1A16 and 28.	63
20379614	2010	Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.	62
15057901	2004	Variation of hepatic glucuronidation: Novel functional polymorphisms of the UDP-glucuronosyltransferase UGT1A4.	37
19244109	2009	Functional significance of UDP-glucuronosyltransferase variants in the metabolism of active tamoxifen metabolites.	25
20297805	2010	Use of glucuronidation fingerprinting to describe and predict mono- and dihydroxyflavone metabolism by recombinant UGT isoforms and human intestinal and liver microsomes.	22
18052087	2007	Disposition of flavonoids via enteric recycling: enzyme stability affects characterization of prunetin glucuronidation across species, organs, and UGT isoforms.	18
15117964	2004	Gastrointestinally distributed UDP-glucuronosyltransferase 1A10, which metabolizes estrogens and nonsteroidal anti-inflammatory drugs, depends upon phosphorylation.	17
16475821	2006	Phenylalanine 90 and 93 are localized within the phenol binding site of human UDP-glucuronosyltransferase 1A10 as determined by photoaffinity labeling, mass spectrometry, and site-directed mutagenesis.	15

Citation

Dessen P

UGT1A10 (UDP glucuronosyltransferase family 1 member A10)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46276/ugt1a10