Atlas of Genetics and Cytogenetics in Oncology and Haematology

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UGT1A7 (UDP glucuronosyltransferase family 1 member A7)

Identity

Alias_namesUDP glycosyltransferase 1 family, polypeptide A7
Alias_symbol (synonym)UGT1G
Other aliasGNT1
UDPGT
UDPGT 1-7
UGT-1A
UGT-1G
UGT1
UGT1-01
UGT1-07
UGT1.1
UGT1.7
UGT1A
UGT1A1
hUG-BR1
HGNC (Hugo) UGT1A7
LocusID (NCBI) 54577
Atlas_Id 45712
Location 2q37.1  [Link to chromosome band 2q37]
Location_base_pair Starts at 233681938 and ends at 233773299 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)UGT1A7   12539
Cards
Entrez_Gene (NCBI)UGT1A7  54577  UDP glucuronosyltransferase family 1 member A7
AliasesGNT1; UDPGT; UDPGT; UGT-1A; 
UGT-1G; UGT1; UGT1-01; UGT1-07; UGT1.1; UGT1.7; UGT1A; UGT1A1; UGT1G; hUG-BR1
GeneCards (Weizmann)UGT1A7
Ensembl hg19 (Hinxton)ENSG00000244122 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000244122 [Gene_View]  ENSG00000244122 [Sequence]  chr2:233681938-233773299 [Contig_View]  UGT1A7 [Vega]
ICGC DataPortalENSG00000244122
TCGA cBioPortalUGT1A7
AceView (NCBI)UGT1A7
Genatlas (Paris)UGT1A7
WikiGenes54577
SOURCE (Princeton)UGT1A7
Genetics Home Reference (NIH)UGT1A7
Genomic and cartography
GoldenPath hg38 (UCSC)UGT1A7  -     chr2:233681938-233773299 +  2q37.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)UGT1A7  -     2q37.1   [Description]    (hg19-Feb_2009)
GoldenPathUGT1A7 - 2q37.1 [CytoView hg19]  UGT1A7 - 2q37.1 [CytoView hg38]
Genome Data Viewer NCBIUGT1A7 [Mapview hg19]  
OMIM606432   
Gene and transcription
Genbank (Entrez)AY435142 BC001521 DQ383513 U89507
RefSeq transcript (Entrez)NM_019077
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)UGT1A7
Alternative Splicing GalleryENSG00000244122
Gene ExpressionUGT1A7 [ NCBI-GEO ]   UGT1A7 [ EBI - ARRAY_EXPRESS ]   UGT1A7 [ SEEK ]   UGT1A7 [ MEM ]
Gene Expression Viewer (FireBrowse)UGT1A7 [ Firebrowse - Broad ]
GenevisibleExpression of UGT1A7 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)54577
GTEX Portal (Tissue expression)UGT1A7
Human Protein AtlasENSG00000244122-UGT1A7 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9HAW7   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9HAW7  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9HAW7
Splice isoforms : SwissVarQ9HAW7
Catalytic activity : Enzyme2.4.1.17 [ Enzyme-Expasy ]   2.4.1.172.4.1.17 [ IntEnz-EBI ]   2.4.1.17 [ BRENDA ]   2.4.1.17 [ KEGG ]   [ MEROPS ]
PhosPhoSitePlusQ9HAW7
Domaine pattern : Prosite (Expaxy)UDPGT (PS00375)   
Domains : Interpro (EBI)UDP_glucos_trans    UDP_glycos_trans_CS   
Domain families : Pfam (Sanger)UDPGT (PF00201)   
Domain families : Pfam (NCBI)pfam00201   
Conserved Domain (NCBI)UGT1A7
DMDM Disease mutations54577
SuperfamilyQ9HAW7
Human Protein Atlas [tissue]ENSG00000244122-UGT1A7 [tissue]
Peptide AtlasQ9HAW7
HPRD09397
IPIIPI00384872   IPI00956477   IPI00956507   IPI00946102   
Protein Interaction databases
DIP (DOE-UCLA)Q9HAW7
IntAct (EBI)Q9HAW7
FunCoupENSG00000244122
BioGRIDUGT1A7
STRING (EMBL)UGT1A7
ZODIACUGT1A7
Ontologies - Pathways
QuickGOQ9HAW7
Ontology : AmiGOretinoic acid binding  enzyme inhibitor activity  protein kinase C binding  endoplasmic reticulum  endoplasmic reticulum membrane  excretion  coumarin metabolic process  glucuronosyltransferase activity  integral component of membrane  drug metabolic process  enzyme binding  retinoic acid metabolic process  protein homodimerization activity  negative regulation of catalytic activity  flavone metabolic process  cellular glucuronidation  flavonoid glucuronidation  flavonoid glucuronidation  xenobiotic glucuronidation  xenobiotic glucuronidation  
Ontology : EGO-EBIretinoic acid binding  enzyme inhibitor activity  protein kinase C binding  endoplasmic reticulum  endoplasmic reticulum membrane  excretion  coumarin metabolic process  glucuronosyltransferase activity  integral component of membrane  drug metabolic process  enzyme binding  retinoic acid metabolic process  protein homodimerization activity  negative regulation of catalytic activity  flavone metabolic process  cellular glucuronidation  flavonoid glucuronidation  flavonoid glucuronidation  xenobiotic glucuronidation  xenobiotic glucuronidation  
Pathways : KEGGPentose and glucuronate interconversions    Ascorbate and aldarate metabolism    Steroid hormone biosynthesis    Starch and sucrose metabolism    Retinol metabolism    Porphyrin and chlorophyll metabolism    Metabolism of xenobiotics by cytochrome P450    Drug metabolism - cytochrome P450    Drug metabolism - other enzymes    Chemical carcinogenesis   
NDEx NetworkUGT1A7
Atlas of Cancer Signalling NetworkUGT1A7
Wikipedia pathwaysUGT1A7
Orthology - Evolution
OrthoDB54577
GeneTree (enSembl)ENSG00000244122
Phylogenetic Trees/Animal Genes : TreeFamUGT1A7
HOGENOMQ9HAW7
Homologs : HomoloGeneUGT1A7
Homology/Alignments : Family Browser (UCSC)UGT1A7
Gene fusions - Rearrangements
Fusion : QuiverUGT1A7
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerUGT1A7 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)UGT1A7
dbVarUGT1A7
ClinVarUGT1A7
1000_GenomesUGT1A7 
Exome Variant ServerUGT1A7
GNOMAD BrowserENSG00000244122
Varsome BrowserUGT1A7
Genetic variants : HAPMAP54577
Genomic Variants (DGV)UGT1A7 [DGVbeta]
DECIPHERUGT1A7 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisUGT1A7 
Mutations
ICGC Data PortalUGT1A7 
TCGA Data PortalUGT1A7 
Broad Tumor PortalUGT1A7
OASIS PortalUGT1A7 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICUGT1A7  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DUGT1A7
Mutations and Diseases : HGMDUGT1A7
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutaselect UGT1A7
DgiDB (Drug Gene Interaction Database)UGT1A7
DoCM (Curated mutations)UGT1A7 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)UGT1A7 (select a term)
intoGenUGT1A7
Cancer3DUGT1A7 (select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM606432   
Orphanet
DisGeNETUGT1A7
MedgenUGT1A7
Genetic Testing Registry UGT1A7
NextProtQ9HAW7 [Medical]
TSGene54577
GENETestsUGT1A7
Open Targets GeneticsENSG00000244122  [validation]
snp3D : Map Gene to Disease54577
BioCentury BCIQUGT1A7
ClinGenUGT1A7
Clinical trials, drugs, therapy
Protein Interactions : CTD54577
Pharm GKB GenePA37182
Pharm GKB PathwaysPA165964832   PA166123135   
Clinical trialUGT1A7
Miscellaneous
canSAR (ICR)UGT1A7 (select the gene name)
HarmonizomeUGT1A7
DataMed IndexUGT1A7
Probes
Litterature
PubMed102 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineUGT1A7
EVEXUGT1A7
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Sat Jul 11 20:17:46 CEST 2020
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