Identity
HGNC
LOCATION
2q37.1
LOCUSID
ALIAS
GNT1,UDPGT,UDPGT
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 54576
MIM: 606433
HGNC: 12540
Ensembl: ENSG00000242366
Variants:
dbSNP: 54576
ClinVar: 54576
TCGA: ENSG00000242366
COSMIC: UGT1A8
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000242366 | ENST00000373450 | Q9HAW9 |
| ENSG00000242366 | ENST00000373450 | Q5DSZ6 |
Expression (GTEx)
Pathways
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA164748728 | mycophenolic acid | Chemical | MultilinkAnnotation, Pathway | associated | 24220207 | ||
| PA165110775 | SN-38 | Chemical | Pathway | associated | |||
| PA165817016 | Kidney Transplantation | Disease | ClinicalAnnotation | associated | PD | 20565459 | |
| PA165958521 | febuxostat | Chemical | ClinicalAnnotation | associated | PD | 27798726 | |
| PA166048848 | Menopause | Disease | ClinicalAnnotation | associated | PD | 27546373 | |
| PA166104276 | ABT-751 | Chemical | ClinicalAnnotation | associated | PK | 23670235 | |
| PA420 | UGT1A1 | Gene | VipGene | associated | 15179404, 18004212, 18491077, 18518849, 19794410, 19997083, 8467709, 11434514 | ||
| PA444065 | Epilepsy | Disease | ClinicalAnnotation | associated | PK | PD | 15761113, 21806385, 27900402, 28763744 |
| PA444318 | Gout | Disease | ClinicalAnnotation | associated | PD | 27798726 | |
| PA445062 | Neoplasms | Disease | ClinicalAnnotation | associated | PK | 23670235 | |
| PA445601 | Osteosarcoma | Disease | ClinicalAnnotation | associated | PK | 29791011 | |
| PA445629 | Seizures | Disease | ClinicalAnnotation | associated | PD | 27900402 | |
| PA447216 | Schizophrenia | Disease | ClinicalAnnotation | associated | PD | 27546373 | |
| PA448320 | allopurinol | Chemical | ClinicalAnnotation | associated | PD | 27798726 | |
| PA449167 | cyclosporine | Chemical | ClinicalAnnotation | associated | PD | 20565459 | |
| PA450428 | methotrexate | Chemical | ClinicalAnnotation | associated | PK | 29791011 | |
| PA450566 | mycophenolate mofetil | Chemical | ClinicalAnnotation | associated | PD | 20565459 | |
| PA450732 | oxcarbazepine | Chemical | ClinicalAnnotation | associated | PD | 27900402 | |
| PA451221 | raloxifene | Chemical | ClinicalAnnotation, VariantAnnotation | associated | PK | PD | 27546373 |
| PA451257 | risperidone | Chemical | ClinicalAnnotation | associated | PD | ||
| PA451365 | sirolimus | Chemical | ClinicalAnnotation | associated | PD | 20565459 | |
| PA451578 | tacrolimus | Chemical | ClinicalAnnotation | associated | PD | 20565459 | |
| PA451846 | valproic acid | Chemical | ClinicalAnnotation, VariantAnnotation | associated | PK | PD | 15761113, 21806385, 28763744 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 32592099 | 2020 | The function of uterine UDP-glucuronosyltransferase 1A8 (UGT1A8) and UDP-glucuronosyltransferase 2B7 (UGT2B7) is involved in endometrial cancer based on estrogen metabolism regulation. | 5 |
| 32592099 | 2020 | The function of uterine UDP-glucuronosyltransferase 1A8 (UGT1A8) and UDP-glucuronosyltransferase 2B7 (UGT2B7) is involved in endometrial cancer based on estrogen metabolism regulation. | 5 |
| 29025387 | 2018 | In Vitro Study on Influences of UGT1A8 Gene Polymorphisms on Mycophenolate Mofetil Metabolism. | 1 |
| 29519853 | 2018 | Cooperative Regulation of Intestinal UDP-Glucuronosyltransferases 1A8, -1A9, and 1A10 by CDX2 and HNF4α Is Mediated by a Novel Composite Regulatory Element. | 1 |
| 29025387 | 2018 | In Vitro Study on Influences of UGT1A8 Gene Polymorphisms on Mycophenolate Mofetil Metabolism. | 1 |
| 29519853 | 2018 | Cooperative Regulation of Intestinal UDP-Glucuronosyltransferases 1A8, -1A9, and 1A10 by CDX2 and HNF4α Is Mediated by a Novel Composite Regulatory Element. | 1 |
| 29282011 | 2017 | Common variants in glucuronidation enzymes and membrane transporters as potential risk factors for colorectal cancer: a case control study. | 6 |
| 29282011 | 2017 | Common variants in glucuronidation enzymes and membrane transporters as potential risk factors for colorectal cancer: a case control study. | 6 |
| 26247833 | 2016 | Raloxifene glucuronidation in liver and intestinal microsomes of humans and monkeys: contribution of UGT1A1, UGT1A8 and UGT1A9. | 1 |
| 26247833 | 2016 | Raloxifene glucuronidation in liver and intestinal microsomes of humans and monkeys: contribution of UGT1A1, UGT1A8 and UGT1A9. | 1 |
| 26317684 | 2015 | Species- and gender-dependent differences in the glucuronidation of a flavonoid glucoside and its aglycone determined using expressed UGT enzymes and microsomes. | 5 |
| 26317684 | 2015 | Species- and gender-dependent differences in the glucuronidation of a flavonoid glucoside and its aglycone determined using expressed UGT enzymes and microsomes. | 5 |
| 23682072 | 2013 | Characterization of raloxifene glucuronidation: potential role of UGT1A8 genotype on raloxifene metabolism in vivo. | 15 |
| 23700788 | 2013 | Genetic polymorphisms of UGT1A8, UGT1A9, UGT2B7 and ABCC2 in Chinese renal transplant recipients and a comparison with other ethnic populations. | 3 |
| 23721685 | 2013 | Genetic polymorphisms of UGT1A8, UGT1A9 and HNF-1α and gastrointestinal symptoms in renal transplant recipients taking mycophenolic acid. | 2 |
Citation
Dessen P
UGT1A8 (UDP glucuronosyltransferase family 1 member A8)
Atlas Genet Cytogenet Oncol Haematol. 2012-08-01
Online version: http://atlasgeneticsoncology.org/gene/52824/ugt1a8
