Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 54600
MIM: 606434
HGNC: 12541
Ensembl: ENSG00000241119
Variants:
dbSNP: 54600
ClinVar: 54600
TCGA: ENSG00000241119
COSMIC: UGT1A9
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000241119 | ENST00000354728 | O60656 |
| ENSG00000241119 | ENST00000354728 | Q5DSZ5 |
Expression (GTEx)
Pathways
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA164748728 | mycophenolic acid | Chemical | ClinicalAnnotation, MultilinkAnnotation, Pathway | associated | PK | 24220207, 25163792 | |
| PA164888966 | raltegravir | Chemical | VariantAnnotation | associated | PK | ||
| PA165110775 | SN-38 | Chemical | ClinicalAnnotation, Pathway | associated | PK | PD | 12181437, 16636344, 18221820, 24897286 |
| PA165817016 | Kidney Transplantation | Disease | ClinicalAnnotation | associated | PK | PD | 16198654, 18946804, 20565459, 22210424, 22765258, 25163792 |
| PA165958521 | febuxostat | Chemical | ClinicalAnnotation | associated | PD | 27798726 | |
| PA166119041 | drug-induced liver injury | Disease | MultilinkAnnotation | associated | 25446781 | ||
| PA420 | UGT1A1 | Gene | VipGene | associated | 11037804, 11434514, 12019197, 12181437, 12969965, 14647407, 15179404, 1651156, 17058217, 17728214, 18004212, 18349289, 18466101, 18491077, 18518849, 19364970, 19390945, 19794410, 19852077, 19997083, 20562211, 8467709, 10381366 | ||
| PA443622 | Carcinoma, Non-Small-Cell Lung | Disease | ClinicalAnnotation | associated | PK | PD | 16636344, 18221820 |
| PA444065 | Epilepsy | Disease | ClinicalAnnotation | associated | PK | PD | 15761113, 21806385, 27900402, 28763744 |
| PA444318 | Gout | Disease | ClinicalAnnotation | associated | PD | 27798726 | |
| PA445062 | Neoplasms | Disease | ClinicalAnnotation | associated | PD | 22912756 | |
| PA445601 | Osteosarcoma | Disease | ClinicalAnnotation | associated | PK | 29791011 | |
| PA445629 | Seizures | Disease | ClinicalAnnotation | associated | PD | 27900402 | |
| PA446108 | Colorectal Neoplasms | Disease | ClinicalAnnotation | associated | PK | PD | 12181437, 23386248 |
| PA446443 | Liver Failure, Acute | Disease | ClinicalAnnotation | associated | PD | ||
| PA447216 | Schizophrenia | Disease | ClinicalAnnotation | associated | PD | ||
| PA447230 | HIV | Disease | VariantAnnotation | associated | PK | ||
| PA448015 | acetaminophen | Chemical | ClinicalAnnotation, Literature, MultilinkAnnotation, Pathway | associated | PD | 11714888, 16696573, 23279026, 26049587 | |
| PA448320 | allopurinol | Chemical | ClinicalAnnotation | associated | PD | 27798726 | |
| PA449957 | ibuprofen | Chemical | Pathway | associated | 25502615 | ||
| PA450085 | irinotecan | Chemical | ClinicalAnnotation | associated | PK | PD | 12181437, 16636344, 18221820, 23386248 |
| PA450428 | methotrexate | Chemical | ClinicalAnnotation | associated | PK | 29791011 | |
| PA450566 | mycophenolate mofetil | Chemical | ClinicalAnnotation | associated | PK | PD | 16198654, 18946804, 20565459, 22210424, 22765258 |
| PA450731 | oxazepam | Chemical | Pathway | associated | |||
| PA450732 | oxcarbazepine | Chemical | ClinicalAnnotation | associated | PD | 27900402 | |
| PA450911 | phenobarbital | Chemical | Pathway | associated | 26049587 | ||
| PA450947 | phenytoin | Chemical | Pathway | associated | 26049587 | ||
| PA451141 | propofol | Chemical | ClinicalAnnotation, VariantAnnotation | associated | PK | PD | 18816295 |
| PA451257 | risperidone | Chemical | ClinicalAnnotation | associated | PD | ||
| PA451363 | simvastatin | Chemical | ClinicalAnnotation | associated | PD | 25493567 | |
| PA451550 | sulfinpyrazone | Chemical | ClinicalAnnotation | associated | PK | 22981363 | |
| PA451846 | valproic acid | Chemical | ClinicalAnnotation, VariantAnnotation | associated | PK | PD | 15761113, 21806385, 28763744 |
| PA7000 | sorafenib | Chemical | ClinicalAnnotation, Pathway | associated | PD | 22912756, 28362716 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38071562 | 2024 | Cytochrome P450 2B6 and UDP-Glucuronosyltransferase Enzyme-Mediated Clearance of Ciprofol (HSK3486) in Humans: The Role of Hepatic and Extrahepatic Metabolism. | 0 |
| 38071562 | 2024 | Cytochrome P450 2B6 and UDP-Glucuronosyltransferase Enzyme-Mediated Clearance of Ciprofol (HSK3486) in Humans: The Role of Hepatic and Extrahepatic Metabolism. | 0 |
| 36571650 | 2023 | Significance of UGT1A6, UGT1A9, and UGT2B7 genetic variants and their mRNA expression in the clinical outcome of renal cell carcinoma. | 0 |
| 36571650 | 2023 | Significance of UGT1A6, UGT1A9, and UGT2B7 genetic variants and their mRNA expression in the clinical outcome of renal cell carcinoma. | 0 |
| 35807350 | 2022 | UGT1A1 and UGT1A9 Are Responsible for Phase II Metabolism of Tectorigenin and Irigenin In Vitro. | 3 |
| 35807350 | 2022 | UGT1A1 and UGT1A9 Are Responsible for Phase II Metabolism of Tectorigenin and Irigenin In Vitro. | 3 |
| 31959879 | 2020 | Genetic variants in CYP2A6 and UGT1A9 genes associated with urinary nicotine metabolites in young Mexican smokers. | 4 |
| 32222391 | 2020 | Worsening of Kidney Transplant Function During 2-Year Follow-up Is Associated With the Genetic Variants of CYP3A4, MDR1, and UGT1A9. | 0 |
| 31959879 | 2020 | Genetic variants in CYP2A6 and UGT1A9 genes associated with urinary nicotine metabolites in young Mexican smokers. | 4 |
| 32222391 | 2020 | Worsening of Kidney Transplant Function During 2-Year Follow-up Is Associated With the Genetic Variants of CYP3A4, MDR1, and UGT1A9. | 0 |
| 30910587 | 2019 | Epigenetic regulation of UDP-Glucuronosyltransferase by microRNA-200a/-183: implications for responses to sorafenib treatment in patients with hepatocellular carcinoma. | 3 |
| 31470908 | 2019 | Novel analytical methods to interpret large sequencing data from small sample sizes. | 1 |
| 30910587 | 2019 | Epigenetic regulation of UDP-Glucuronosyltransferase by microRNA-200a/-183: implications for responses to sorafenib treatment in patients with hepatocellular carcinoma. | 3 |
| 31470908 | 2019 | Novel analytical methods to interpret large sequencing data from small sample sizes. | 1 |
| 28443723 | 2018 | Glucuronidation of icaritin by human liver microsomes, human intestine microsomes and expressed UDP-glucuronosyltransferase enzymes: identification of UGT1A3, 1A9 and 2B7 as the main contributing enzymes. | 15 |
Citation
Dessen P
UGT1A9 (UDP glucuronosyltransferase family 1 member A9)
Atlas Genet Cytogenet Oncol Haematol. 2003-08-01
Online version: http://atlasgeneticsoncology.org/gene/42764/ugt1a9
