UGT2B10 (UDP glucuronosyltransferase family 2 member B10)

2008-05-01 Affiliation

Identity

HGNC

UGT2B10

LOCATION

4q13.2

LOCUSID

7365

ALIAS

UDPGT2B10

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 7365
MIM: 600070
HGNC: 12544
Ensembl: ENSG00000109181

Variants:

dbSNP: 7365
ClinVar: 7365
TCGA: ENSG00000109181
COSMIC: UGT2B10

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000109181	ENST00000265403	P36537
ENSG00000109181	ENST00000458688	P36537

Expression (GTEx)

100

150

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Pentose and glucuronate interconversions	KEGG	ko00040
Ascorbate and aldarate metabolism	KEGG	ko00053
Steroid hormone biosynthesis	KEGG	ko00140
Retinol metabolism	KEGG	ko00830
Porphyrin and chlorophyll metabolism	KEGG	ko00860
Metabolism of xenobiotics by cytochrome P450	KEGG	ko00980
Drug metabolism - cytochrome P450	KEGG	ko00982
Drug metabolism - other enzymes	KEGG	ko00983
Pentose and glucuronate interconversions	KEGG	hsa00040
Ascorbate and aldarate metabolism	KEGG	hsa00053
Steroid hormone biosynthesis	KEGG	hsa00140
Retinol metabolism	KEGG	hsa00830
Porphyrin and chlorophyll metabolism	KEGG	hsa00860
Metabolism of xenobiotics by cytochrome P450	KEGG	hsa00980
Drug metabolism - cytochrome P450	KEGG	hsa00982
Drug metabolism - other enzymes	KEGG	hsa00983
Metabolic pathways	KEGG	hsa01100
Glucuronate pathway (uronate pathway)	KEGG	M00014
Chemical carcinogenesis	KEGG	hsa05204
Chemical carcinogenesis	KEGG	ko05204
Glucuronate pathway (uronate pathway)	KEGG	hsa_M00014
Metabolism	REACTOME	R-HSA-1430728
Biological oxidations	REACTOME	R-HSA-211859
Phase II conjugation	REACTOME	R-HSA-156580
Glucuronidation	REACTOME	R-HSA-156588

Protein levels (Protein atlas)

Not detected

Low

Medium

High

PharmGKB

Entity ID	Name	Type	Evidence	Association	PK	PD	PMIDs
PA156	ESR1	Gene	Literature, MultilinkAnnotation	associated			24879639
PA166114414	cotinine	Chemical	ClinicalAnnotation	associated	PK
PA445876	Tobacco Use Disorder	Disease	ClinicalAnnotation	associated	PK
PA450626	nicotine	Chemical	ClinicalAnnotation, VariantAnnotation	associated	PK	PD	17909004, 18300939, 24192532

References

Pubmed ID	Year	Title	Citations
25233931	2014	Nicotine N-glucuronidation relative to N-oxidation and C-oxidation and UGT2B10 genotype in five ethnic/racial groups.	66
17909004	2007	Glucuronidation of nicotine and cotinine by UGT2B10: loss of function by the UGT2B10 Codon 67 (Asp>Tyr) polymorphism.	35
20876810	2010	Glucuronidation genotypes and nicotine metabolic phenotypes: importance of functional UGT2B10 and UGT2B17 polymorphisms.	31
20876810	2010	Glucuronidation genotypes and nicotine metabolic phenotypes: importance of functional UGT2B10 and UGT2B17 polymorphisms.	31
17576790	2007	Nicotine glucuronidation and the human UDP-glucuronosyltransferase UGT2B10.	29
18300939	2008	Identification of a prevalent functional missense polymorphism in the UGT2B10 gene and its association with UGT2B10 inactivation against tobacco-specific nitrosamines.	23
18300939	2008	Identification of a prevalent functional missense polymorphism in the UGT2B10 gene and its association with UGT2B10 inactivation against tobacco-specific nitrosamines.	23
20501767	2010	UGT2B10 genotype influences nicotine glucuronidation, oxidation, and consumption.	16
20501767	2010	UGT2B10 genotype influences nicotine glucuronidation, oxidation, and consumption.	16
20799965	2010	Expression levels of uridine 5'-diphospho-glucuronosyltransferase genes in breast tissue from healthy women are associated with mammographic density.	16

Citation

Dessen P

UGT2B10 (UDP glucuronosyltransferase family 2 member B10)

Atlas Genet Cytogenet Oncol Haematol. 2008-05-01

Online version: http://atlasgeneticsoncology.org/gene/50141/ugt2b10