Identity
HGNC
LOCATION
4q13.3
LOCUSID
ALIAS
HLUG25,UDPGT2B4,UDPGTH1,UDPGTh-1,UGT2B11
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 7363
MIM: 600067
HGNC: 12553
Ensembl: ENSG00000156096
Variants:
dbSNP: 7363
ClinVar: 7363
TCGA: ENSG00000156096
COSMIC: UGT2B4
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000156096 | ENST00000305107 | P06133 |
| ENSG00000156096 | ENST00000510114 | D6RGY0 |
| ENSG00000156096 | ENST00000512583 | P06133 |
| ENSG00000156096 | ENST00000639621 | A0A1W2PQJ2 |
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA449957 | ibuprofen | Chemical | Pathway | associated | 25502615 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 36823244 | 2023 | Distilling functional variations for human UGT2B4 upstream region based on selection signals and implications for phenotypes of Neanderthal and Denisovan. | 0 |
| 36823244 | 2023 | Distilling functional variations for human UGT2B4 upstream region based on selection signals and implications for phenotypes of Neanderthal and Denisovan. | 0 |
| 32170986 | 2021 | Absence of significant association between UGT2B4 genetic variants and the susceptibility to anti-tuberculosis drug-induced liver injury in a Western Chinese population. | 1 |
| 32170986 | 2021 | Absence of significant association between UGT2B4 genetic variants and the susceptibility to anti-tuberculosis drug-induced liver injury in a Western Chinese population. | 1 |
| 29138287 | 2018 | Clopidogrel Carboxylic Acid Glucuronidation is Mediated Mainly by UGT2B7, UGT2B4, and UGT2B17: Implications for Pharmacogenetics and Drug-Drug Interactions( ). | 9 |
| 29138287 | 2018 | Clopidogrel Carboxylic Acid Glucuronidation is Mediated Mainly by UGT2B7, UGT2B4, and UGT2B17: Implications for Pharmacogenetics and Drug-Drug Interactions( ). | 9 |
| 27282283 | 2016 | UGT2B4 previously implicated in the risk of breast cancer is associated with menarche timing in Ukrainian females. | 4 |
| 27282283 | 2016 | UGT2B4 previously implicated in the risk of breast cancer is associated with menarche timing in Ukrainian females. | 4 |
| 25948711 | 2015 | Upregulation of UGT2B4 Expression by 3'-Phosphoadenosine-5'-Phosphosulfate Synthase Knockdown: Implications for Coordinated Control of Bile Acid Conjugation. | 2 |
| 25948711 | 2015 | Upregulation of UGT2B4 Expression by 3'-Phosphoadenosine-5'-Phosphosulfate Synthase Knockdown: Implications for Coordinated Control of Bile Acid Conjugation. | 2 |
| 22092298 | 2012 | Methadone inhibits CYP2D6 and UGT2B7/2B4 in vivo: a study using codeine in methadone- and buprenorphine-maintained subjects. | 7 |
| 22367021 | 2012 | High enzyme activity UGT1A1 or low activity UGT1A8 and UGT2B4 genotypes increase esophageal cancer risk. | 14 |
| 22092298 | 2012 | Methadone inhibits CYP2D6 and UGT2B7/2B4 in vivo: a study using codeine in methadone- and buprenorphine-maintained subjects. | 7 |
| 22367021 | 2012 | High enzyme activity UGT1A1 or low activity UGT1A8 and UGT2B4 genotypes increase esophageal cancer risk. | 14 |
| 21660508 | 2011 | A signature of balancing selection in the region upstream to the human UGT2B4 gene and implications for breast cancer risk. | 20 |
Citation
Dessen P
UGT2B4 (UDP glucuronosyltransferase family 2 member B4)
Atlas Genet Cytogenet Oncol Haematol. 2012-08-01
Online version: http://atlasgeneticsoncology.org/gene/52838/ugt2b4
