ULBP2 (UL16 binding protein 2)

2007-12-01  

Identity

HGNC
LOCATION
6q25.1
LOCUSID
ALIAS
ALCAN-alpha,N2DL2,NKG2DL2,RAET1H,RAET1L
FUSION GENES

Other Information

Locus ID:

NCBI: 80328
MIM: 605698
HGNC: 14894
Ensembl: ENSG00000131015

Variants:

dbSNP: 80328
ClinVar: 80328
TCGA: ENSG00000131015
COSMIC: ULBP2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000131015ENST00000367351Q9BZM5

Expression (GTEx)

0
1
2
3
4
5
6
7
8
9
10

Pathways

PathwaySourceExternal ID
Natural killer cell mediated cytotoxicityKEGGko04650
Natural killer cell mediated cytotoxicityKEGGhsa04650
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
Post-translational modification: synthesis of GPI-anchored proteinsREACTOMER-HSA-163125

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
197984332009HIV-1 Vpr triggers natural killer cell-mediated lysis of infected cells through activation of the ATR-mediated DNA damage response.72
221026942012Tumor suppressive microRNAs miR-34a/c control cancer cell expression of ULBP2, a stress-induced ligand of the natural killer cell receptor NKG2D.66
217647622011Human NK cells are alerted to induction of p53 in cancer cells by upregulation of the NKG2D ligands ULBP1 and ULBP2.59
187917132009Clinical significance of the NKG2D ligands, MICA/B and ULBP2 in ovarian cancer: high expression of ULBP2 is an indicator of poor prognosis.56
196718532009Differential clinical significance of individual NKG2D ligands in melanoma: soluble ULBP2 as an indicator of poor prognosis superior to S100B.54
117779602002UL16-binding proteins, novel MHC class I-related proteins, bind to NKG2D and activate multiple signaling pathways in primary NK cells.52
128472602003Effects of human cytomegalovirus infection on ligands for the activating NKG2D receptor of NK cells: up-regulation of UL16-binding protein (ULBP)1 and ULBP2 is counteracted by the viral UL16 protein.47
204281962010The prognostic significance of soluble NKG2D ligands in B-cell chronic lymphocytic leukemia.43
191517702009Effective in vivo induction of NKG2D ligands in acute myeloid leukaemias by all-trans-retinoic acid or sodium valproate.40
150517592004Cell surface organization of stress-inducible proteins ULBP and MICA that stimulate human NK cells and T cells via NKG2D.38

Citation

Dessen P

ULBP2 (UL16 binding protein 2)

Atlas Genet Cytogenet Oncol Haematol. 2007-12-01

Online version: http://atlasgeneticsoncology.org/gene/49898/ulbp2