ULK1 (unc-51 like autophagy activating kinase 1)

2006-10-01  

Identity

HGNC
LOCATION
12q24.33
LOCUSID
ALIAS
ATG1,ATG1A,UNC51,Unc51.1,hATG1
FUSION GENES

Other Information

Locus ID:

NCBI: 8408
MIM: 603168
HGNC: 12558
Ensembl: ENSG00000177169

Variants:

dbSNP: 8408
ClinVar: 8408
TCGA: ENSG00000177169
COSMIC: ULK1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000177169ENST00000321867O75385

Expression (GTEx)

0
50
100
150

Pathways

PathwaySourceExternal ID
Autophagy - animalKEGGko04140
mTOR signaling pathwayKEGGko04150
Autophagy - animalKEGGhsa04140
mTOR signaling pathwayKEGGhsa04150
AMPK signaling pathwayKEGGhsa04152
AMPK signaling pathwayKEGGko04152
Vesicle-mediated transportREACTOMER-HSA-5653656
Membrane TraffickingREACTOMER-HSA-199991
Cellular responses to stressREACTOMER-HSA-2262752
MacroautophagyREACTOMER-HSA-1632852
Longevity regulating pathwayKEGGhsa04211
RAB GEFs exchange GTP for GDP on RABsREACTOMER-HSA-8876198
TBC/RABGAPsREACTOMER-HSA-8854214
Mitophagy - animalKEGGko04137
Mitophagy - animalKEGGhsa04137

References

Pubmed IDYearTitleCitations
212583672011AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1.1800
212056412011Phosphorylation of ULK1 (hATG1) by AMP-activated protein kinase connects energy sensing to mitophagy.855
192251512009ULK-Atg13-FIP200 complexes mediate mTOR signaling to the autophagy machinery.679
192118352009Nutrient-dependent mTORC1 association with the ULK1-Atg13-FIP200 complex required for autophagy.642
192583182009ULK1.ATG13.FIP200 complex mediates mTOR signaling and is essential for autophagy.479
169403482006Starvation and ULK1-dependent cycling of mammalian Atg9 between the TGN and endosomes.286
235249512013mTOR inhibits autophagy by controlling ULK1 ubiquitylation, self-association and function through AMBRA1 and TRAF6.237
241198412013Cyclic dinucleotides trigger ULK1 (ATG1) phosphorylation of STING to prevent sustained innate immune signaling.186
175951592007siRNA screening of the kinome identifies ULK1 as a multidomain modulator of autophagy.180
189361572009Kinase-inactivated ULK proteins inhibit autophagy via their conserved C-terminal domains using an Atg13-independent mechanism.178

Citation

Dessen P

ULK1 (unc-51 like autophagy activating kinase 1)

Atlas Genet Cytogenet Oncol Haematol. 2006-10-01

Online version: http://atlasgeneticsoncology.org/gene/43551/ulk1