Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 7372
MIM: 613891
HGNC: 12563
Ensembl: ENSG00000114491
Variants:
dbSNP: 7372
ClinVar: 7372
TCGA: ENSG00000114491
COSMIC: UMPS
RNA/Proteins
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA128406956 | fluorouracil | Chemical | ClinicalAnnotation | associated | PK | PD | 16818689, 20647221 |
| PA443448 | Asthenia | Disease | ClinicalAnnotation | associated | PD | 28347776 | |
| PA443937 | Drug Toxicity | Disease | ClinicalAnnotation | associated | PK | PD | 16818689, 20647221 |
| PA445048 | Nausea | Disease | ClinicalAnnotation | associated | PD | 28347776 | |
| PA445058 | Neoplasm Metastasis | Disease | ClinicalAnnotation | associated | PD | ||
| PA445062 | Neoplasms | Disease | ClinicalAnnotation | associated | PD | 28347776 | |
| PA446051 | Vomiting | Disease | ClinicalAnnotation | associated | PD | 28347776 | |
| PA448771 | capecitabine | Chemical | ClinicalAnnotation | associated | PK | PD | 16818689, 20647221, 28347776 |
| PA450198 | leucovorin | Chemical | ClinicalAnnotation | associated | PK | PD | 16818689, 20647221 |
| PA452620 | tegafur | Chemical | ClinicalAnnotation | associated | PK | PD | 16818689, 20647221 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 36708921 | 2023 | Human uridine 5'-monophosphate synthase stores metabolic potential in inactive biomolecular condensates. | 0 |
| 36708921 | 2023 | Human uridine 5'-monophosphate synthase stores metabolic potential in inactive biomolecular condensates. | 0 |
| 32382150 | 2020 | LncRNA SNORD3A specifically sensitizes breast cancer cells to 5-FU by sponging miR-185-5p to enhance UMPS expression. | 19 |
| 32382150 | 2020 | LncRNA SNORD3A specifically sensitizes breast cancer cells to 5-FU by sponging miR-185-5p to enhance UMPS expression. | 19 |
| 28205048 | 2017 | Mild orotic aciduria in UMPS heterozygotes: a metabolic finding without clinical consequences. | 5 |
| 28347333 | 2017 | A phase II study of preoperative chemoradiation with tegafur-uracil plus leucovorin for locally advanced rectal cancer with pharmacogenetic analysis. | 4 |
| 28205048 | 2017 | Mild orotic aciduria in UMPS heterozygotes: a metabolic finding without clinical consequences. | 5 |
| 28347333 | 2017 | A phase II study of preoperative chemoradiation with tegafur-uracil plus leucovorin for locally advanced rectal cancer with pharmacogenetic analysis. | 4 |
| 22249354 | 2013 | Novel mRNA isoforms and mutations of uridine monophosphate synthetase and 5-fluorouracil resistance in colorectal cancer. | 18 |
| 24158442 | 2013 | Transition state analogues of Plasmodium falciparum and human orotate phosphoribosyltransferases. | 9 |
| 22249354 | 2013 | Novel mRNA isoforms and mutations of uridine monophosphate synthetase and 5-fluorouracil resistance in colorectal cancer. | 18 |
| 24158442 | 2013 | Transition state analogues of Plasmodium falciparum and human orotate phosphoribosyltransferases. | 9 |
| 22641663 | 2012 | Expression of dihydropyrimidine dehydrogenase, orotate phosphoribosyl transferase and thymidylate synthase in patients with primary colorectal cancer, and associations with site of first metastasis. | 4 |
| 22931617 | 2012 | [Expressions of orotate phosphoribosyltransferase in colorectal carcinoma and its correlations with toxicities of chemotherapy]. | 1 |
| 22641663 | 2012 | Expression of dihydropyrimidine dehydrogenase, orotate phosphoribosyl transferase and thymidylate synthase in patients with primary colorectal cancer, and associations with site of first metastasis. | 4 |
Citation
Dessen P
UMPS (uridine monophosphate synthetase)
Atlas Genet Cytogenet Oncol Haematol. 2006-10-01
Online version: http://atlasgeneticsoncology.org/gene/43555/umps
