Identity
HGNC
LOCATION
15q26.1
LOCUSID
ALIAS
GC-UNC45,GCUNC-45,GCUNC45,IRO039700,SMAP-1,SMAP1,UNC-45A
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 55898
MIM: 611219
HGNC: 30594
Ensembl: ENSG00000140553
Variants:
dbSNP: 55898
ClinVar: 55898
TCGA: ENSG00000140553
COSMIC: UNC45A
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000140553 | ENST00000394275 | Q9H3U1 |
| ENSG00000140553 | ENST00000418476 | Q9H3U1 |
| ENSG00000140553 | ENST00000639885 | A0A1W2PNX8 |
Expression (GTEx)
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 37328071 | 2023 | Aagenaes syndrome/lymphedema cholestasis syndrome 1 is caused by a founder variant in the 5'-untranslated region of UNC45A. | 1 |
| 37328071 | 2023 | Aagenaes syndrome/lymphedema cholestasis syndrome 1 is caused by a founder variant in the 5'-untranslated region of UNC45A. | 1 |
| 35344227 | 2022 | A myosin chaperone, UNC-45A, is a novel regulator of intestinal epithelial barrier integrity and repair. | 8 |
| 35421597 | 2022 | A Functional Relationship Between UNC45A and MYO5B Connects Two Rare Diseases With Shared Enteropathy. | 6 |
| 35575086 | 2022 | UNC45A deficiency causes microvillus inclusion disease-like phenotype by impairing myosin VB-dependent apical trafficking. | 7 |
| 35344227 | 2022 | A myosin chaperone, UNC-45A, is a novel regulator of intestinal epithelial barrier integrity and repair. | 8 |
| 35421597 | 2022 | A Functional Relationship Between UNC45A and MYO5B Connects Two Rare Diseases With Shared Enteropathy. | 6 |
| 35575086 | 2022 | UNC45A deficiency causes microvillus inclusion disease-like phenotype by impairing myosin VB-dependent apical trafficking. | 7 |
| 33262310 | 2021 | UNC-45A breaks the microtubule lattice independently of its effects on non-muscle myosin II. | 7 |
| 33262310 | 2021 | UNC-45A breaks the microtubule lattice independently of its effects on non-muscle myosin II. | 7 |
| 30322860 | 2019 | UNC-45A Is a Novel Microtubule-Associated Protein and Regulator of Paclitaxel Sensitivity in Ovarian Cancer Cells. | 16 |
| 30737284 | 2019 | The co-chaperone UNC45A is essential for the expression of mitotic kinase NEK7 and tumorigenesis. | 20 |
| 30322860 | 2019 | UNC-45A Is a Novel Microtubule-Associated Protein and Regulator of Paclitaxel Sensitivity in Ovarian Cancer Cells. | 16 |
| 30737284 | 2019 | The co-chaperone UNC45A is essential for the expression of mitotic kinase NEK7 and tumorigenesis. | 20 |
| 29288355 | 2018 | UCS protein function is partially restored in the Saccharomyces cerevisiae she4 mutant with expression of the human UNC45-GC, but not UNC45-SM. | 4 |
Citation
Dessen P
UNC45A (unc-45 myosin chaperone A)
Atlas Genet Cytogenet Oncol Haematol. 2007-02-01
Online version: http://atlasgeneticsoncology.org/gene/50036/unc45a
