UNC45A (unc-45 myosin chaperone A)

2007-02-01  

Identity

HGNC
UNC45A
LOCATION
15q26.1
LOCUSID
55898
ALIAS
GC-UNC45,GCUNC-45,GCUNC45,IRO039700,SMAP-1,SMAP1,UNC-45A
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 55898
MIM: 611219
HGNC: 30594
Ensembl: ENSG00000140553

Variants:

dbSNP: 55898
ClinVar: 55898
TCGA: ENSG00000140553
COSMIC: UNC45A

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000140553ENST00000394275Q9H3U1
ENSG00000140553ENST00000418476Q9H3U1
ENSG00000140553ENST00000639885A0A1W2PNX8

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
164789932006GCUNC-45 is a novel regulator for the progesterone receptor/hsp90 chaperoning pathway.30
178729782007Myosin II co-chaperone general cell UNC-45 overexpression is associated with ovarian cancer, rapid proliferation, and motility.20
182853462008GCUNC45 is the first Hsp90 co-chaperone to show alpha/beta isoform specificity.16
290550112017UNC-45a promotes myosin folding and stress fiber assembly.13
218024252011Differential turnover of myosin chaperone UNC-45A isoforms increases in metastatic human breast cancer.11
264385242015UNC-45A Is a Nonmuscle Myosin IIA Chaperone Required for NK Cell Cytotoxicity via Control of Lytic Granule Secretion.11
254449112015UNC45A localizes to centrosomes and regulates cancer cell proliferation through ChK1 activation.6
283564212017UNC-45A is required for neurite extension via controlling NMII activation.4
303228602019UNC-45A Is a Novel Microtubule-Associated Protein and Regulator of Paclitaxel Sensitivity in Ovarian Cancer Cells.4
307372842019The co-chaperone UNC45A is essential for the expression of mitotic kinase NEK7 and tumorigenesis.3

Citation

Dessen P

UNC45A (unc-45 myosin chaperone A)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/50036/unc45a