Atlas of Genetics and Cytogenetics in Oncology and Haematology

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UNC5A (unc-5 netrin receptor A)

Identity

Alias_namesunc5 (C.elegans homolog) a
unc-5 homolog A (C. elegans)
Alias_symbol (synonym)KIAA1976
UNC5H1
Other alias
HGNC (Hugo) UNC5A
LocusID (NCBI) 90249
Atlas_Id 43649
Location 5q35.2  [Link to chromosome band 5q35]
Location_base_pair Starts at 176810559 and ends at 176880898 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
NSD1 (5q35.2) / UNC5A (5q35.2)UNC5A (5q35.2) / TTC38 (22q13.31)UNC5A (5q35.2) / UNC5A (5q35.2)
NSD1 5q35.2 / UNC5A 5q35.2UNC5A 5q35.2 / TTC38 22q13.31

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 2 ]
  NSD1/UNC5A (5q35)
t(5;22)(q35;q13) UNC5A/TTC38

External links

Nomenclature
HGNC (Hugo)UNC5A   12567
Cards
Entrez_Gene (NCBI)UNC5A  90249  unc-5 netrin receptor A
AliasesUNC5H1
GeneCards (Weizmann)UNC5A
Ensembl hg19 (Hinxton)ENSG00000113763 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000113763 [Gene_View]  ENSG00000113763 [Sequence]  chr5:176810559-176880898 [Contig_View]  UNC5A [Vega]
ICGC DataPortalENSG00000113763
TCGA cBioPortalUNC5A
AceView (NCBI)UNC5A
Genatlas (Paris)UNC5A
WikiGenes90249
SOURCE (Princeton)UNC5A
Genetics Home Reference (NIH)UNC5A
Genomic and cartography
GoldenPath hg38 (UCSC)UNC5A  -     chr5:176810559-176880898 +  5q35.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)UNC5A  -     5q35.2   [Description]    (hg19-Feb_2009)
GoldenPathUNC5A - 5q35.2 [CytoView hg19]  UNC5A - 5q35.2 [CytoView hg38]
ImmunoBaseENSG00000113763
Mapping of homologs : NCBIUNC5A [Mapview hg19]  UNC5A [Mapview hg38]
OMIM607869   
Gene and transcription
Genbank (Entrez)AB075856 AK131380 BC009333 BC033727 BC122556
RefSeq transcript (Entrez)NM_133369
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)UNC5A
Cluster EST : UnigeneHs.33191 [ NCBI ]
CGAP (NCI)Hs.33191
Alternative Splicing GalleryENSG00000113763
Gene ExpressionUNC5A [ NCBI-GEO ]   UNC5A [ EBI - ARRAY_EXPRESS ]   UNC5A [ SEEK ]   UNC5A [ MEM ]
Gene Expression Viewer (FireBrowse)UNC5A [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)90249
GTEX Portal (Tissue expression)UNC5A
Human Protein AtlasENSG00000113763-UNC5A [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ6ZN44   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ6ZN44  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ6ZN44
Splice isoforms : SwissVarQ6ZN44
PhosPhoSitePlusQ6ZN44
Domaine pattern : Prosite (Expaxy)IG_LIKE (PS50835)    TSP1 (PS50092)    ZU5 (PS51145)   
Domains : Interpro (EBI)DEATH-like_dom_sf    Death_domain    Ig-like_dom    Ig-like_dom_sf    Ig-like_fold    Ig_I-set    Ig_sub    TSP1_rpt    TSP1_rpt_sf    UNC5    UPA    ZU5_dom   
Domain families : Pfam (Sanger)Death (PF00531)    I-set (PF07679)    UPA (PF17217)    ZU5 (PF00791)   
Domain families : Pfam (NCBI)pfam00531    pfam07679    pfam17217    pfam00791   
Domain families : Smart (EMBL)DEATH (SM00005)  IG (SM00409)  TSP1 (SM00209)  ZU5 (SM00218)  
Conserved Domain (NCBI)UNC5A
DMDM Disease mutations90249
Blocks (Seattle)UNC5A
PDB (RSDB)4V2A   
PDB Europe4V2A   
PDB (PDBSum)4V2A   
PDB (IMB)4V2A   
Structural Biology KnowledgeBase4V2A   
SCOP (Structural Classification of Proteins)4V2A   
CATH (Classification of proteins structures)4V2A   
SuperfamilyQ6ZN44
Human Protein Atlas [tissue]ENSG00000113763-UNC5A [tissue]
Peptide AtlasQ6ZN44
IPIIPI00470692   IPI00418573   IPI00176345   IPI00966212   IPI00966471   
Protein Interaction databases
DIP (DOE-UCLA)Q6ZN44
IntAct (EBI)Q6ZN44
FunCoupENSG00000113763
BioGRIDUNC5A
STRING (EMBL)UNC5A
ZODIACUNC5A
Ontologies - Pathways
QuickGOQ6ZN44
Ontology : AmiGOnetrin receptor activity  plasma membrane  apoptotic process  axon guidance  axon guidance  integral component of membrane  neuron projection development  intrinsic component of plasma membrane  neuron projection membrane  neuronal cell body membrane  anterior/posterior axon guidance  netrin-activated signaling pathway  membrane raft  
Ontology : EGO-EBInetrin receptor activity  plasma membrane  apoptotic process  axon guidance  axon guidance  integral component of membrane  neuron projection development  intrinsic component of plasma membrane  neuron projection membrane  neuronal cell body membrane  anterior/posterior axon guidance  netrin-activated signaling pathway  membrane raft  
Pathways : KEGGAxon guidance   
NDEx NetworkUNC5A
Atlas of Cancer Signalling NetworkUNC5A
Wikipedia pathwaysUNC5A
Orthology - Evolution
OrthoDB90249
GeneTree (enSembl)ENSG00000113763
Phylogenetic Trees/Animal Genes : TreeFamUNC5A
HOGENOMQ6ZN44
Homologs : HomoloGeneUNC5A
Homology/Alignments : Family Browser (UCSC)UNC5A
Gene fusions - Rearrangements
Fusion : MitelmanNSD1/UNC5A [5q35.2/5q35.2]  [t(5;5)(q35;q35)]  
Fusion : MitelmanUNC5A/TTC38 [5q35.2/22q13.31]  [t(5;22)(q35;q13)]  
Fusion PortalNSD1 5q35.2 UNC5A 5q35.2 LUAD
Fusion PortalUNC5A 5q35.2 TTC38 22q13.31 OV
Fusion : QuiverUNC5A
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerUNC5A [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)UNC5A
dbVarUNC5A
ClinVarUNC5A
1000_GenomesUNC5A 
Exome Variant ServerUNC5A
ExAC (Exome Aggregation Consortium)ENSG00000113763
GNOMAD BrowserENSG00000113763
Varsome BrowserUNC5A
Genetic variants : HAPMAP90249
Genomic Variants (DGV)UNC5A [DGVbeta]
DECIPHERUNC5A [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisUNC5A 
Mutations
ICGC Data PortalUNC5A 
TCGA Data PortalUNC5A 
Broad Tumor PortalUNC5A
OASIS PortalUNC5A [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICUNC5A  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DUNC5A
Mutations and Diseases : HGMDUNC5A
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch UNC5A
DgiDB (Drug Gene Interaction Database)UNC5A
DoCM (Curated mutations)UNC5A (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)UNC5A (select a term)
intoGenUNC5A
Cancer3DUNC5A(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM607869   
Orphanet
DisGeNETUNC5A
MedgenUNC5A
Genetic Testing Registry UNC5A
NextProtQ6ZN44 [Medical]
TSGene90249
GENETestsUNC5A
Target ValidationUNC5A
Huge Navigator UNC5A [HugePedia]
snp3D : Map Gene to Disease90249
BioCentury BCIQUNC5A
ClinGenUNC5A
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD90249
Chemical/Pharm GKB GenePA37204
Clinical trialUNC5A
Miscellaneous
canSAR (ICR)UNC5A (select the gene name)
DataMed IndexUNC5A
Probes
Litterature
PubMed22 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineUNC5A
EVEXUNC5A
GoPubMedUNC5A
iHOPUNC5A
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Nov 13 18:14:19 CET 2019
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