UNC5C (unc-5 netrin receptor C)

2007-02-01  

Identity

HGNC
LOCATION
4q22.3
LOCUSID
ALIAS
UNC5H3
FUSION GENES

Other Information

Locus ID:

NCBI: 8633
MIM: 603610
HGNC: 12569
Ensembl: ENSG00000182168

Variants:

dbSNP: 8633
ClinVar: 8633
TCGA: ENSG00000182168
COSMIC: UNC5C

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000182168ENST00000453304O95185
ENSG00000182168ENST00000504962D6RE16
ENSG00000182168ENST00000506749O95185
ENSG00000182168ENST00000513796E0CX15
ENSG00000182168ENST00000610318A0A087X152

Expression (GTEx)

0
5
10
15

Pathways

PathwaySourceExternal ID
Axon guidanceKEGGko04360
Axon guidanceKEGGhsa04360
Developmental BiologyREACTOMER-HSA-1266738
Axon guidanceREACTOMER-HSA-422475
Netrin-1 signalingREACTOMER-HSA-373752
Netrin mediated repulsion signalsREACTOMER-HSA-418886

References

Pubmed IDYearTitleCitations
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
126550552003The netrin-1 receptors UNC5H are putative tumor suppressors controlling cell death commitment.55
254197062014A rare mutation in UNC5C predisposes to late-onset Alzheimer's disease and increases neuronal cell death.48
202019262010Human variation in alcohol response is influenced by variation in neuronal signaling genes.45
179674592007Inactivation of the UNC5C Netrin-1 receptor is associated with tumor progression in colorectal malignancies.44
180545572007Epigenetic and genetic alterations in Netrin-1 receptors UNC5C and DCC in human colon cancer.38
253168122014Whole-exome sequencing of muscle-invasive bladder cancer identifies recurrent mutations of UNC5C and prognostic importance of DNA repair gene mutations on survival.32
155747332004Mapping netrin receptor binding reveals domains of Unc5 regulating its tyrosine phosphorylation.27
198502832010Identification of novel candidate genes for treatment response to risperidone and susceptibility for schizophrenia: integrated analysis among pharmacogenomics, mouse expression, and genetic case-control association approaches.27
268594572016Structural Decoding of the Netrin-1/UNC5 Interaction and its Therapeutical Implications in Cancers.25

Citation

Dessen P

UNC5C (unc-5 netrin receptor C)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45616/unc5c