UNC5D (unc-5 netrin receptor D)

2014-02-01  

Identity

HGNC
LOCATION
8p12
LOCUSID
ALIAS
PRO34692,Unc5h4
FUSION GENES

Other Information

Locus ID:

NCBI: 137970
MIM: 616466
HGNC: 18634
Ensembl: ENSG00000156687

Variants:

dbSNP: 137970
ClinVar: 137970
TCGA: ENSG00000156687
COSMIC: UNC5D

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000156687ENST00000287272H7BXJ2
ENSG00000156687ENST00000404895Q6UXZ4
ENSG00000156687ENST00000416672C9J2B6
ENSG00000156687ENST00000420357C9J1I0
ENSG00000156687ENST00000449677E9PDS8
ENSG00000156687ENST00000453357Q6UXZ4

Expression (GTEx)

0
1
2
3
4
5
6

Pathways

PathwaySourceExternal ID
Axon guidanceKEGGko04360
Axon guidanceKEGGhsa04360
Developmental BiologyREACTOMER-HSA-1266738
Axon guidanceREACTOMER-HSA-422475
Netrin-1 signalingREACTOMER-HSA-373752
Netrin mediated repulsion signalsREACTOMER-HSA-418886

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
237781382013Dependence receptor UNC5D mediates nerve growth factor depletion-induced neuroblastoma regression.15
184027672008A newly identified dependence receptor UNC5H4 is induced during DNA damage-mediated apoptosis and transcriptional target of tumor suppressor p53.11
235891792013The tumor-suppressive function of UNC5D and its repressed expression in renal cell carcinoma.7
246916572014Unc5D regulates p53-dependent apoptosis in neuroblastoma cells.4
287541762017Genome-wide gene by lead exposure interaction analysis identifies UNC5D as a candidate gene for neurodevelopment.4
306326692019UNC5D, suppressed by promoter hypermethylation, inhibits cell metastasis by activating death-associated protein kinase 1 in prostate cancer.3
245190682014Overexpression of the dependence receptor UNC5H4 inhibits cell migration and invasion, and triggers apoptosis in neuroblastoma cell.0

Citation

Dessen P

UNC5D (unc-5 netrin receptor D)

Atlas Genet Cytogenet Oncol Haematol. 2014-02-01

Online version: http://atlasgeneticsoncology.org/gene/53800/unc5d