UPK3A (uroplakin 3A)

2007-02-01  

Identity

HGNC
UPK3A
LOCATION
22q13.31
LOCUSID
7380
ALIAS
UP3A,UPIII,UPIIIA,UPK3
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 7380
MIM: 611559
HGNC: 12580
Ensembl: ENSG00000100373

Variants:

dbSNP: 7380
ClinVar: 7380
TCGA: ENSG00000100373
COSMIC: UPK3A

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000100373ENST00000216211O75631
ENSG00000100373ENST00000396082O75631

Expression (GTEx)

0
5
10
15
20
25
30
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Bladder cancerKEGGko05219
Bladder cancerKEGGhsa05219

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
194123412009Bacteria-induced uroplakin signaling mediates bladder response to infection.66
146545292003Impaired p63 expression associates with poor prognosis and uroplakin III expression in invasive urothelial carcinoma of the bladder.38
199597182010Whole-genome linkage and association scan in primary, nonsyndromic vesicoureteric reflux.20
190079072009Differentiation-induced uroplakin III expression promotes urothelial cell death in response to uropathogenic E. coli.18
167312952006Mutations in Uroplakin IIIA are a rare cause of renal hypodysplasia in humans.12
183131202008Loss expression of uroplakin III is associated with clinicopathologic features of aggressive bladder cancer.11
176981282007Uroplakin III-delta4 messenger RNA as a promising marker to identify nonulcerative interstitial cystitis.10
147138562004No pathogenic mutations in the uroplakin III gene of 25 patients with primary vesicoureteral reflux.9
178802892007Up-regulation of urinary UPIII mRNA levels in vesicoureteral reflux patients: potential application as a screening test for vesicoureteral reflux.1
245533012014Significance of uroplakin III expression in recurrence of solitary muscle non-invasive bladder cancer.1

Citation

Dessen P

UPK3A (uroplakin 3A)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46005/upk3a