UQCRH (ubiquinol-cytochrome c reductase hinge protein)

2003-05-01  

Identity

HGNC
LOCATION
1p33
LOCUSID
ALIAS
QCR6,UQCR8
FUSION GENES

Other Information

Locus ID:

NCBI: 7388
MIM: 613844
HGNC: 12590
Ensembl: ENSG00000173660

Variants:

dbSNP: 7388
ClinVar: 7388
TCGA: ENSG00000173660
COSMIC: UQCRH

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000173660ENST00000311672P07919
ENSG00000173660ENST00000489056A0A087X2B9
ENSG00000173660ENST00000496387A0A087WTF2

Expression (GTEx)

0
100
200
300
400
500
600
700

Pathways

PathwaySourceExternal ID
Oxidative phosphorylationKEGGko00190
Alzheimer's diseaseKEGGko05010
Huntington's diseaseKEGGko05016
Oxidative phosphorylationKEGGhsa00190
Alzheimer's diseaseKEGGhsa05010
Parkinson's diseaseKEGGhsa05012
Huntington's diseaseKEGGhsa05016
Cardiac muscle contractionKEGGhsa04260
Cardiac muscle contractionKEGGko04260
Metabolic pathwaysKEGGhsa01100
Cytochrome bc1 complexKEGGhsa_M00152
Cytochrome bc1 complexKEGGM00152
Non-alcoholic fatty liver disease (NAFLD)KEGGhsa04932
Non-alcoholic fatty liver disease (NAFLD)KEGGko04932
MetabolismREACTOMER-HSA-1430728
The citric acid (TCA) cycle and respiratory electron transportREACTOMER-HSA-1428517
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.REACTOMER-HSA-163200
Respiratory electron transportREACTOMER-HSA-611105

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
208776242010Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.17
283323142017The mitochondrial hinge protein, UQCRH, is a novel prognostic factor for hepatocellular carcinoma.9
128817162003UQCRH gene encoding mitochondrial Hinge protein is interrupted by a translocation in a soft-tissue sarcoma and epigenetically inactivated in some cancer cell lines.6

Citation

Dessen P

UQCRH (ubiquinol-cytochrome c reductase hinge protein)

Atlas Genet Cytogenet Oncol Haematol. 2003-05-01

Online version: http://atlasgeneticsoncology.org/gene/420/uqcrh