Atlas of Genetics and Cytogenetics in Oncology and Haematology

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URI1 (URI1 prefoldin like chaperone)

Identity

Alias (NCBI)C19orf2
NNX3
PPP1R19
RMP
URI
HGNC (Hugo) URI1
HGNC Alias symbRMP
NNX3
FLJ10575
URI
PPP1R19
HGNC Alias nameunconventional prefoldin RPB5 interactor
 RPB5-mediating protein
 protein phosphatase 1, regulatory subunit 19
HGNC Previous nameC19orf2
HGNC Previous namechromosome 19 open reading frame 2
LocusID (NCBI) 8725
Atlas_Id 52232
Location 19q12  [Link to chromosome band 19q12]
Location_base_pair Starts at 29942239 and ends at 30016612 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
URI1 (19q12) / IFNL1 (19q13.2)URI1 (19q12) / URI1 (19q12)URI1 (19q12) / VSTM2B (19q12)
URI1 (19q12) / XRCC1 (19q13.31)URI1 (19q12) / ZNF383 (19q13.12)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 3 ]
  t(19;19)(q12;q13) URI1/IFNL1
t(19;19)(q12;q13) URI1/XRCC1
t(19;19)(q12;q13) URI1/ZNF383

External links

Nomenclature
HGNC (Hugo)URI1   13236
Cards
Entrez_Gene (NCBI)URI1  8725  URI1 prefoldin like chaperone
AliasesC19orf2; NNX3; PPP1R19; RMP; 
URI
GeneCards (Weizmann)URI1
Ensembl hg19 (Hinxton)ENSG00000105176 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000105176 [Gene_View]  ENSG00000105176 [Sequence]  chr19:29942239-30016612 [Contig_View]  URI1 [Vega]
ICGC DataPortalENSG00000105176
TCGA cBioPortalURI1
AceView (NCBI)URI1
Genatlas (Paris)URI1
WikiGenes8725
SOURCE (Princeton)URI1
Genetics Home Reference (NIH)URI1
Genomic and cartography
GoldenPath hg38 (UCSC)URI1  -     chr19:29942239-30016612 +  19q12   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)URI1  -     19q12   [Description]    (hg19-Feb_2009)
GoldenPathURI1 - 19q12 [CytoView hg19]  URI1 - 19q12 [CytoView hg38]
ImmunoBaseENSG00000105176
genome Data Viewer NCBIURI1 [Mapview hg19]  
OMIM603494   
Gene and transcription
Genbank (Entrez)AA678820 AF091095 AK001437 AK226173 AK292170
RefSeq transcript (Entrez)NM_001252641 NM_003796 NM_134447
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)URI1
Alternative Splicing GalleryENSG00000105176
Gene ExpressionURI1 [ NCBI-GEO ]   URI1 [ EBI - ARRAY_EXPRESS ]   URI1 [ SEEK ]   URI1 [ MEM ]
Gene Expression Viewer (FireBrowse)URI1 [ Firebrowse - Broad ]
GenevisibleExpression of URI1 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)8725
GTEX Portal (Tissue expression)URI1
Human Protein AtlasENSG00000105176-URI1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO94763   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO94763  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO94763
Splice isoforms : SwissVarO94763
PhosPhoSitePlusO94763
Domains : Interpro (EBI)Prefoldin    Prefoldin_subunit_alpha   
Domain families : Pfam (Sanger)Prefoldin (PF02996)   
Domain families : Pfam (NCBI)pfam02996   
Conserved Domain (NCBI)URI1
DMDM Disease mutations8725
Blocks (Seattle)URI1
SuperfamilyO94763
Human Protein Atlas [tissue]ENSG00000105176-URI1 [tissue]
Peptide AtlasO94763
HPRD11943
IPIIPI00477619   IPI01015668   IPI00939535   IPI00743872   
Protein Interaction databases
DIP (DOE-UCLA)O94763
IntAct (EBI)O94763
FunCoupENSG00000105176
BioGRIDURI1
STRING (EMBL)URI1
ZODIACURI1
Ontologies - Pathways
QuickGOO94763
Ontology : AmiGOnegative regulation of transcription by RNA polymerase II  negative regulation of transcription by RNA polymerase II  RNA polymerase II complex binding  regulation of cell growth  chromatin binding  chromatin binding  transcription corepressor activity  transcription corepressor activity  transcription corepressor activity  protein phosphatase inhibitor activity  protein binding  nucleus  nucleoplasm  cytoplasm  mitochondrion  cytosol  regulation of transcription by RNA polymerase II  response to virus  negative regulation of phosphatase activity  negative regulation of phosphatase activity  phosphatase inhibitor activity  dendrite  negative regulation of phosphoprotein phosphatase activity  phosphoprotein binding  cellular response to growth factor stimulus  cellular response to steroid hormone stimulus  negative regulation of intrinsic apoptotic signaling pathway  
Ontology : EGO-EBInegative regulation of transcription by RNA polymerase II  negative regulation of transcription by RNA polymerase II  RNA polymerase II complex binding  regulation of cell growth  chromatin binding  chromatin binding  transcription corepressor activity  transcription corepressor activity  transcription corepressor activity  protein phosphatase inhibitor activity  protein binding  nucleus  nucleoplasm  cytoplasm  mitochondrion  cytosol  regulation of transcription by RNA polymerase II  response to virus  negative regulation of phosphatase activity  negative regulation of phosphatase activity  phosphatase inhibitor activity  dendrite  negative regulation of phosphoprotein phosphatase activity  phosphoprotein binding  cellular response to growth factor stimulus  cellular response to steroid hormone stimulus  negative regulation of intrinsic apoptotic signaling pathway  
NDEx NetworkURI1
Atlas of Cancer Signalling NetworkURI1
Wikipedia pathwaysURI1
Orthology - Evolution
OrthoDB8725
GeneTree (enSembl)ENSG00000105176
Phylogenetic Trees/Animal Genes : TreeFamURI1
HOGENOMO94763
Homologs : HomoloGeneURI1
Homology/Alignments : Family Browser (UCSC)URI1
Gene fusions - Rearrangements
Fusion : MitelmanURI1/IFNL1 [19q12/19q13.2]  
Fusion : MitelmanURI1/XRCC1 [19q12/19q13.31]  
Fusion : MitelmanURI1/ZNF383 [19q12/19q13.12]  
Fusion : QuiverURI1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerURI1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)URI1
dbVarURI1
ClinVarURI1
1000_GenomesURI1 
Exome Variant ServerURI1
GNOMAD BrowserENSG00000105176
Varsome BrowserURI1
Genetic variants : HAPMAP8725
Genomic Variants (DGV)URI1 [DGVbeta]
DECIPHERURI1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisURI1 
Mutations
ICGC Data PortalURI1 
TCGA Data PortalURI1 
Broad Tumor PortalURI1
OASIS PortalURI1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICURI1  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DURI1
Mutations and Diseases : HGMDURI1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch URI1
DgiDB (Drug Gene Interaction Database)URI1
DoCM (Curated mutations)URI1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)URI1 (select a term)
intoGenURI1
Cancer3DURI1(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM603494   
Orphanet
DisGeNETURI1
MedgenURI1
Genetic Testing Registry URI1
NextProtO94763 [Medical]
TSGene8725
GENETestsURI1
Target ValidationURI1
Huge Navigator URI1 [HugePedia]
snp3D : Map Gene to Disease8725
BioCentury BCIQURI1
ClinGenURI1
Clinical trials, drugs, therapy
Protein Interactions : CTD8725
Pharm GKB GenePA134962614
Clinical trialURI1
Miscellaneous
canSAR (ICR)URI1 (select the gene name)
HarmonizomeURI1
DataMed IndexURI1
Probes
Litterature
PubMed65 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineURI1
EVEXURI1
GoPubMedURI1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Thu Jul 16 15:41:49 CEST 2020
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