URM1 (ubiquitin related modifier 1)

2014-11-01  

Identity

HGNC
LOCATION
9q34.11
LOCUSID
ALIAS
C9orf74
FUSION GENES

Other Information

Locus ID:

NCBI: 81605
MIM: 612693
HGNC: 28378
Ensembl: ENSG00000167118

Variants:

dbSNP: 81605
ClinVar: 81605
TCGA: ENSG00000167118
COSMIC: URM1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000167118ENST00000372847Q5T4A9
ENSG00000167118ENST00000372850Q9BTM9
ENSG00000167118ENST00000372853Q9BTM9
ENSG00000167118ENST00000372853A0A024R8C7
ENSG00000167118ENST00000470840Q5T4A9

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
50

Pathways

PathwaySourceExternal ID
Sulfur relay systemKEGGko04122
Sulfur relay systemKEGGhsa04122
Gene ExpressionREACTOMER-HSA-74160
tRNA processingREACTOMER-HSA-72306
tRNA modification in the nucleus and cytosolREACTOMER-HSA-6782315

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
190178112008A functional proteomics approach links the ubiquitin-related modifier Urm1 to a tRNA modification pathway.61
212093362011Role of the ubiquitin-like protein Urm1 as a noncanonical lysine-directed protein modifier.45
184919212008The sulfurtransferase activity of Uba4 presents a link between ubiquitin-like protein conjugation and activation of sulfur carrier proteins.40
212453322011Urm1 couples sulfur transfer to ubiquitin-like protein function in oxidative stress.13
257473902015Urmylation and tRNA thiolation functions of ubiquitin-like Uba4·Urm1 systems are conserved from yeast to man.12

Citation

Dessen P

URM1 (ubiquitin related modifier 1)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/75514/urm1