USE1 (unconventional SNARE in the ER 1)

2014-11-01  

Identity

HGNC
LOCATION
19p13.11
LOCUSID
ALIAS
D12,MDS032,P31,SLT1

Other Information

Locus ID:

NCBI: 55850
MIM: 610675
HGNC: 30882
Ensembl: ENSG00000053501

Variants:

dbSNP: 55850
ClinVar: 55850
TCGA: ENSG00000053501
COSMIC: USE1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000053501ENST00000263897Q9NZ43
ENSG00000053501ENST00000445667G8JLK1
ENSG00000053501ENST00000593597M0QYT5
ENSG00000053501ENST00000594724M0QZZ6
ENSG00000053501ENST00000595101Q9NZ43
ENSG00000053501ENST00000596136Q9NZ43
ENSG00000053501ENST00000600970M0QZE0
ENSG00000053501ENST00000601662M0QZZ6

Expression (GTEx)

0
5
10
15
20
25
30

Pathways

PathwaySourceExternal ID
SNARE interactions in vesicular transportKEGGko04130
SNARE interactions in vesicular transportKEGGhsa04130
Vesicle-mediated transportREACTOMER-HSA-5653656
Membrane TraffickingREACTOMER-HSA-199991
Intra-Golgi and retrograde Golgi-to-ER trafficREACTOMER-HSA-6811442
Golgi-to-ER retrograde transportREACTOMER-HSA-8856688
COPI-dependent Golgi-to-ER retrograde trafficREACTOMER-HSA-6811434

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
193694182009Identification of the neuroblastoma-amplified gene product as a component of the syntaxin 18 complex implicated in Golgi-to-endoplasmic reticulum retrograde transport.32
209756832010USE1 is a bispecific conjugating enzyme for ubiquitin and FAT10, which FAT10ylates itself in cis.27
245289252014Investigations into the auto-FAT10ylation of the bispecific E2 conjugating enzyme UBA6-specific E2 enzyme 1.8
275692862016LMO2 blocks the UBA6-USE1 interaction and downstream FAT10ylation by targeting the ubiquitin fold domain of UBA6.5
251843402014Grsf1-induced translation of the SNARE protein Use1 is required for expansion of the erythroid compartment.4

Citation

Dessen P

USE1 (unconventional SNARE in the ER 1)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/75517/use1