USP17L2 (ubiquitin specific peptidase 17 like family member 2)

2010-05-01  

Identity

HGNC
USP17L2
LOCATION
8p23.1
LOCUSID
377630
ALIAS
DUB-3,DUB3,USP17

Other Information

Locus ID:

NCBI: 377630
MIM: 610186
HGNC: 34434
Ensembl: ENSG00000223443

Variants:

dbSNP: 377630
ClinVar: 377630
TCGA: ENSG00000223443
COSMIC: USP17L2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000223443ENST00000333796Q6R6M4

Expression (GTEx)

0
1
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
DeubiquitinationREACTOMER-HSA-5688426
Ub-specific processing proteasesREACTOMER-HSA-5689880

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
202288082010Ubiquitin hydrolase Dub3 promotes oncogenic transformation by stabilizing Cdc25A.60
281983612017Dub3 inhibition suppresses breast cancer invasion and metastasis by promoting Snail1 degradation.26
300571992018DUB3 Promotes BET Inhibitor Resistance and Cancer Progression by Deubiquitinating BRD4.20
237734372013Molecular mechanisms and functions of cytokine-inducible deubiquitinating enzymes.13
307184312019MGMT-activated DUB3 stabilizes MCL1 and drives chemoresistance in ovarian cancer.8
282881342017DUB3 and USP7 de-ubiquitinating enzymes control replication inhibitor Geminin: molecular characterization and associations with breast cancer.7
266177812015USP17-mediated deubiquitination and stabilization of HDAC2 in cigarette smoke extract-induced inflammation.6
309351082019Deubiquitinase DUB3 Regulates Cell Cycle Progression via Stabilizing Cyclin A for Proliferation of Non-Small Cell Lung Cancer Cells.5
146991242004DUB-3, a cytokine-inducible deubiquitinating enzyme that blocks proliferation.0
197180262009Personalized copy number and segmental duplication maps using next-generation sequencing.0

Citation

Dessen P

USP17L2 (ubiquitin specific peptidase 17 like family member 2)

Atlas Genet Cytogenet Oncol Haematol. 2010-05-01

Online version: http://atlasgeneticsoncology.org/gene/51473/usp17l2