USP2 (ubiquitin specific peptidase 2)

2007-02-01 Affiliation

Identity

HGNC

USP2

LOCATION

11q23.3

LOCUSID

9099

ALIAS

UBP41,USP9

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 9099
MIM: 604725
HGNC: 12618
Ensembl: ENSG00000036672

Variants:

dbSNP: 9099
ClinVar: 9099
TCGA: ENSG00000036672
COSMIC: USP2

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000036672	ENST00000260187	O75604
ENSG00000036672	ENST00000455332	O75604
ENSG00000036672	ENST00000525735	O75604
ENSG00000036672	ENST00000527843	E9PJ34
ENSG00000036672	ENST00000531070	E9PSH6

Expression (GTEx)

100

150

200

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Metabolism of proteins	REACTOME	R-HSA-392499
Post-translational protein modification	REACTOME	R-HSA-597592
Signal Transduction	REACTOME	R-HSA-162582
Death Receptor Signalling	REACTOME	R-HSA-73887
TNF signaling	REACTOME	R-HSA-75893
TNFR1-induced proapoptotic signaling	REACTOME	R-HSA-5357786
Gene Expression	REACTOME	R-HSA-74160
Generic Transcription Pathway	REACTOME	R-HSA-212436
Transcriptional Regulation by TP53	REACTOME	R-HSA-3700989
TNFR1-induced NFkappaB signaling pathway	REACTOME	R-HSA-5357956
Regulation of TNFR1 signaling	REACTOME	R-HSA-5357905
Regulation of TP53 Activity	REACTOME	R-HSA-5633007
Regulation of TP53 Expression and Degradation	REACTOME	R-HSA-6806003
Regulation of TP53 Degradation	REACTOME	R-HSA-6804757
Deubiquitination	REACTOME	R-HSA-5688426
Ub-specific processing proteases	REACTOME	R-HSA-5689880

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
15050917	2004	The isopeptidase USP2a regulates the stability of fatty acid synthase in prostate cancer.	106
17290220	2007	The deubiquitinating enzyme USP2a regulates the p53 pathway by targeting Mdm2.	105
19917254	2009	Suppression of cancer cell growth by promoting cyclin D1 degradation.	78
19838211	2010	MdmX is a substrate for the deubiquitinating enzyme USP2a.	40
21826056	2011	Nodular fasciitis: a novel model of transient neoplasia induced by MYH9-USP6 gene fusion.	35
22179575	2012	De-ubiquitinating protease USP2a targets RIP1 and TRAF2 to mediate cell death by TNF.	27
27681596	2016	Small Molecule Inhibition of the Ubiquitin-specific Protease USP2 Accelerates cyclin D1 Degradation and Leads to Cell Cycle Arrest in Colorectal Cancer and Mantle Cell Lymphoma Models.	27
22611252	2013	USP2a negatively regulates IL-1β- and virus-induced NF-κB activation by deubiquitinating TRAF6.	26
21480224	2011	An RNAi screen identifies USP2 as a factor required for TNF-α-induced NF-κB signaling.	24
22710717	2013	The ubiquitin-specific protease USP2a prevents endocytosis-mediated EGFR degradation.	23

Citation

Dessen P

USP2 (ubiquitin specific peptidase 2)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46243/usp2