USP21 (ubiquitin specific peptidase 21)

2018-02-01  

Identity

HGNC
LOCATION
1q23.3
LOCUSID
ALIAS
USP16,USP23
FUSION GENES

Other Information

Locus ID:

NCBI: 27005
MIM: 604729
HGNC: 12620
Ensembl: ENSG00000143258

Variants:

dbSNP: 27005
ClinVar: 27005
TCGA: ENSG00000143258
COSMIC: USP21

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000143258ENST00000289865Q9UK80
ENSG00000143258ENST00000368001Q9UK80
ENSG00000143258ENST00000368002Q9UK80
ENSG00000143258ENST00000479344V9GYJ6
ENSG00000143258ENST00000486299A0A1W2PRX0
ENSG00000143258ENST00000492950V9GY36
ENSG00000143258ENST00000493054A0A1W2PQ32

Expression (GTEx)

0
10
20
30
40
50
60

Pathways

PathwaySourceExternal ID
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
Signal TransductionREACTOMER-HSA-162582
Death Receptor SignallingREACTOMER-HSA-73887
TNF signalingREACTOMER-HSA-75893
TNFR1-induced proapoptotic signalingREACTOMER-HSA-5357786
TNFR1-induced NFkappaB signaling pathwayREACTOMER-HSA-5357956
Regulation of TNFR1 signalingREACTOMER-HSA-5357905
DeubiquitinationREACTOMER-HSA-5688426
Ub-specific processing proteasesREACTOMER-HSA-5689880

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
213996172011Polyubiquitin binding and cross-reactivity in the USP domain deubiquitinase USP21.68
199104672010Ubiquitin-specific peptidase 21 inhibits tumor necrosis factor alpha-induced nuclear factor kappaB activation via binding to and deubiquitinating receptor-interacting protein 1.52
222984302012Systematic survey of deubiquitinase localization identifies USP21 as a regulator of centrosome- and microtubule-associated functions.38
233958192013Identification of the E3 deubiquitinase ubiquitin-specific peptidase 21 (USP21) as a positive regulator of the transcription factor GATA3.35
272592572016Ubiquitin specific peptidase 21 regulates interleukin-8 expression, stem-cell like property of human renal cell carcinoma.21
282549482017p38 inhibition provides anti-DNA virus immunity by regulation of USP21 phosphorylation and STING activation.15
276210832016The centrosomal deubiquitylase USP21 regulates Gli1 transcriptional activity and stability.13
274368992016Saturation scanning of ubiquitin variants reveals a common hot spot for binding to USP2 and USP21.12
287439572017Ubiquitin-specific protease 21 stabilizes BRCA2 to control DNA repair and tumor growth.12
251973642014Deubiquitination and stabilization of IL-33 by USP21.10

Citation

Dessen P

USP21 (ubiquitin specific peptidase 21)

Atlas Genet Cytogenet Oncol Haematol. 2018-02-01

Online version: http://atlasgeneticsoncology.org/gene/57285/usp21