USP25 (ubiquitin specific peptidase 25)

2003-02-01  

Identity

HGNC
LOCATION
21q21.1
LOCUSID
ALIAS
USP21
FUSION GENES

Other Information

Locus ID:

NCBI: 29761
MIM: 604736
HGNC: 12624
Ensembl: ENSG00000155313

Variants:

dbSNP: 29761
ClinVar: 29761
TCGA: ENSG00000155313
COSMIC: USP25

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000155313ENST00000285679Q9UHP3
ENSG00000155313ENST00000285681Q9UHP3
ENSG00000155313ENST00000351097Q96B65
ENSG00000155313ENST00000400183Q9UHP3
ENSG00000155313ENST00000449491H7C1T8
ENSG00000155313ENST00000453553H7C253

Expression (GTEx)

0
10
20
30
40
50
60
70
80

Pathways

PathwaySourceExternal ID
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
DeubiquitinationREACTOMER-HSA-5688426
Ub-specific processing proteasesREACTOMER-HSA-5689880
IL-17 signaling pathwayKEGGko04657
IL-17 signaling pathwayKEGGhsa04657

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
185386592008Mechanism and consequences for paralog-specific sumoylation of ubiquitin-specific protease 25.83
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
249977982014miRNA-200c inhibits invasion and metastasis of human non-small cell lung cancer by directly targeting ubiquitin specific peptidase 25.48
185239972008Detailed characterization of a homozygously deleted region corresponding to a candidate tumor suppressor locus at 21q11-21 in human lung cancer.34
214800032011PTMs in conversation: activity and function of deubiquitinating enzymes regulated via post-translational modifications.30
225905602012Ubiquitin-specific protease 25 functions in Endoplasmic Reticulum-associated degradation.28
194403612009The UBA-UIM domains of the USP25 regulate the enzyme ubiquitination state and modulate substrate recognition.25
276933472017Genome-Wide Association Study Identifies African-Specific Susceptibility Loci in African Americans With Inflammatory Bowel Disease.24
242605252013Ubiquitin-specific proteases 25 negatively regulates virus-induced type I interferon signaling.21
115973352001Characterization of alternatively spliced products and tissue-specific isoforms of USP28 and USP25.16

Citation

Dessen P

USP25 (ubiquitin specific peptidase 25)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/429/usp25