USP28 (ubiquitin specific peptidase 28)

2007-09-01  

Identity

HGNC
USP28
LOCATION
11q23.2
LOCUSID
57646
ALIAS
-
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 57646
MIM: 610748
HGNC: 12625
Ensembl: ENSG00000048028

Variants:

dbSNP: 57646
ClinVar: 57646
TCGA: ENSG00000048028
COSMIC: USP28

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000048028ENST00000003302Q96RU2
ENSG00000048028ENST00000535607H0YFA0
ENSG00000048028ENST00000537490H0YH19
ENSG00000048028ENST00000537642H0YFX3
ENSG00000048028ENST00000537706Q96RU2
ENSG00000048028ENST00000538224H0YFT9
ENSG00000048028ENST00000538475H0YG96
ENSG00000048028ENST00000540438F5GZ74
ENSG00000048028ENST00000540925F5H2G4
ENSG00000048028ENST00000544750F5H6Q3
ENSG00000048028ENST00000544967G3V1N5
ENSG00000048028ENST00000545540B4E3L3
ENSG00000048028ENST00000545608H0YFD7

Expression (GTEx)

0
5
10
15
20
25
30
35
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
DeubiquitinationREACTOMER-HSA-5688426
Ub-specific processing proteasesREACTOMER-HSA-5689880

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
175583972007The ubiquitin-specific protease USP28 is required for MYC stability.139
169017862006A role for the deubiquitinating enzyme USP28 in control of the DNA-damage response.131
178735222007Fbw7 and Usp28 regulate myc protein stability in response to DNA damage.52
221441792012GSK-3β regulates cell growth, migration, and angiogenesis via Fbw7 and USP28-dependent degradation of HIF-1α.51
27432897201653BP1 and USP28 mediate p53 activation and G1 arrest after centrosome loss or extended mitotic duration.48
240759932013The deubiquitinase USP28 stabilizes LSD1 and confers stem-cell-like traits to breast cancer cells.46
274328962016A USP28-53BP1-p53-p21 signaling axis arrests growth after centrosome loss or prolonged mitosis.44
249601592014The deubiquitinase USP28 controls intestinal homeostasis and promotes colorectal cancer.34
27546791201653BP1 Integrates DNA Repair and p53-Dependent Cell Fate Decisions via Distinct Mechanisms.34
27371829201653BP1 and USP28 mediate p53-dependent cell cycle arrest in response to centrosome loss and prolonged mitosis.33

Citation

Dessen P

USP28 (ubiquitin specific peptidase 28)

Atlas Genet Cytogenet Oncol Haematol. 2007-09-01

Online version: http://atlasgeneticsoncology.org/gene/49733/usp28