Atlas of Genetics and Cytogenetics in Oncology and Haematology

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USP3 (ubiquitin specific peptidase 3)

Identity

Alias_namesubiquitin specific protease 3
Other aliasSIH003
UBP
HGNC (Hugo) USP3
LocusID (NCBI) 9960
Atlas_Id 51611
Location 15q22.31  [Link to chromosome band 15q22]
Location_base_pair Starts at 63504511 and ends at 63594640 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
HERC1 (15q22.31) / USP3 (15q22.31)USP3 (15q22.31) / SOD1 (21q22.11)USP3 (15q22.31) / USP3 (15q22.31)
ZFC3H1 (12q21.1) / USP3 (15q22.31)HERC1 15q22.31 / USP3 15q22.31

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  HERC1/USP3 (15q22)

External links

Nomenclature
HGNC (Hugo)USP3   12626
Cards
Entrez_Gene (NCBI)USP3  9960  ubiquitin specific peptidase 3
AliasesSIH003; UBP
GeneCards (Weizmann)USP3
Ensembl hg19 (Hinxton)ENSG00000140455 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000140455 [Gene_View]  ENSG00000140455 [Sequence]  chr15:63504511-63594640 [Contig_View]  USP3 [Vega]
ICGC DataPortalENSG00000140455
TCGA cBioPortalUSP3
AceView (NCBI)USP3
Genatlas (Paris)USP3
WikiGenes9960
SOURCE (Princeton)USP3
Genetics Home Reference (NIH)USP3
Genomic and cartography
GoldenPath hg38 (UCSC)USP3  -     chr15:63504511-63594640 +  15q22.31   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)USP3  -     15q22.31   [Description]    (hg19-Feb_2009)
GoldenPathUSP3 - 15q22.31 [CytoView hg19]  USP3 - 15q22.31 [CytoView hg38]
ImmunoBaseENSG00000140455
Mapping of homologs : NCBIUSP3 [Mapview hg19]  USP3 [Mapview hg38]
OMIM604728   
Gene and transcription
Genbank (Entrez)AF073344 AF077040 AI695842 AK022931 AK094444
RefSeq transcript (Entrez)NM_001256702 NM_006537
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)USP3
Cluster EST : UnigeneHs.458499 [ NCBI ]
CGAP (NCI)Hs.458499
Alternative Splicing GalleryENSG00000140455
Gene ExpressionUSP3 [ NCBI-GEO ]   USP3 [ EBI - ARRAY_EXPRESS ]   USP3 [ SEEK ]   USP3 [ MEM ]
Gene Expression Viewer (FireBrowse)USP3 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)9960
GTEX Portal (Tissue expression)USP3
Human Protein AtlasENSG00000140455-USP3 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9Y6I4   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9Y6I4  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9Y6I4
Splice isoforms : SwissVarQ9Y6I4
PhosPhoSitePlusQ9Y6I4
Domaine pattern : Prosite (Expaxy)USP_1 (PS00972)    USP_2 (PS00973)    USP_3 (PS50235)    ZF_UBP (PS50271)   
Domains : Interpro (EBI)Peptidase_C19_UCH    USP_CS    USP_dom    Znf_RING/FYVE/PHD    Znf_UBP   
Domain families : Pfam (Sanger)UCH (PF00443)    zf-UBP (PF02148)   
Domain families : Pfam (NCBI)pfam00443    pfam02148   
Domain families : Smart (EMBL)ZnF_UBP (SM00290)  
Conserved Domain (NCBI)USP3
DMDM Disease mutations9960
Blocks (Seattle)USP3
SuperfamilyQ9Y6I4
Human Protein Atlas [tissue]ENSG00000140455-USP3 [tissue]
Peptide AtlasQ9Y6I4
HPRD05290
IPIIPI00002330   IPI01009341   IPI01009992   IPI01008797   IPI01010279   IPI01015614   IPI00791885   
Protein Interaction databases
DIP (DOE-UCLA)Q9Y6I4
IntAct (EBI)Q9Y6I4
FunCoupENSG00000140455
BioGRIDUSP3
STRING (EMBL)USP3
ZODIACUSP3
Ontologies - Pathways
QuickGOQ9Y6I4
Ontology : AmiGOnegative regulation of transcription by RNA polymerase II  mitotic cell cycle  nuclear chromatin  RNA polymerase II proximal promoter sequence-specific DNA binding  thiol-dependent ubiquitin-specific protease activity  nucleus  nucleus  nucleoplasm  nucleoplasm  cytoplasm  DNA repair  ubiquitin-dependent protein catabolic process  zinc ion binding  histone deubiquitination  histone deubiquitination  protein deubiquitination  regulation of protein stability  cytoplasmic ribonucleoprotein granule  histone binding  Flemming body  promoter-specific chromatin binding  
Ontology : EGO-EBInegative regulation of transcription by RNA polymerase II  mitotic cell cycle  nuclear chromatin  RNA polymerase II proximal promoter sequence-specific DNA binding  thiol-dependent ubiquitin-specific protease activity  nucleus  nucleus  nucleoplasm  nucleoplasm  cytoplasm  DNA repair  ubiquitin-dependent protein catabolic process  zinc ion binding  histone deubiquitination  histone deubiquitination  protein deubiquitination  regulation of protein stability  cytoplasmic ribonucleoprotein granule  histone binding  Flemming body  promoter-specific chromatin binding  
NDEx NetworkUSP3
Atlas of Cancer Signalling NetworkUSP3
Wikipedia pathwaysUSP3
Orthology - Evolution
OrthoDB9960
GeneTree (enSembl)ENSG00000140455
Phylogenetic Trees/Animal Genes : TreeFamUSP3
HOGENOMQ9Y6I4
Homologs : HomoloGeneUSP3
Homology/Alignments : Family Browser (UCSC)USP3
Gene fusions - Rearrangements
Fusion : MitelmanHERC1/USP3 [15q22.31/15q22.31]  [t(15;15)(q22;q22)]  
Fusion PortalHERC1 15q22.31 USP3 15q22.31 BRCA
Fusion : QuiverUSP3
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerUSP3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)USP3
dbVarUSP3
ClinVarUSP3
1000_GenomesUSP3 
Exome Variant ServerUSP3
ExAC (Exome Aggregation Consortium)ENSG00000140455
GNOMAD BrowserENSG00000140455
Varsome BrowserUSP3
Genetic variants : HAPMAP9960
Genomic Variants (DGV)USP3 [DGVbeta]
DECIPHERUSP3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisUSP3 
Mutations
ICGC Data PortalUSP3 
TCGA Data PortalUSP3 
Broad Tumor PortalUSP3
OASIS PortalUSP3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICUSP3  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DUSP3
Mutations and Diseases : HGMDUSP3
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch USP3
DgiDB (Drug Gene Interaction Database)USP3
DoCM (Curated mutations)USP3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)USP3 (select a term)
intoGenUSP3
Cancer3DUSP3(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM604728   
Orphanet
DisGeNETUSP3
MedgenUSP3
Genetic Testing Registry USP3
NextProtQ9Y6I4 [Medical]
TSGene9960
GENETestsUSP3
Target ValidationUSP3
Huge Navigator USP3 [HugePedia]
snp3D : Map Gene to Disease9960
BioCentury BCIQUSP3
ClinGenUSP3
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD9960
Chemical/Pharm GKB GenePA37251
Clinical trialUSP3
Miscellaneous
canSAR (ICR)USP3 (select the gene name)
DataMed IndexUSP3
Probes
Litterature
PubMed31 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineUSP3
EVEXUSP3
GoPubMedUSP3
iHOPUSP3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Nov 13 18:14:36 CET 2019
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