USP33 (ubiquitin specific peptidase 33)

2009-10-01  

Identity

HGNC
USP33
LOCATION
1p31.1
LOCUSID
23032
ALIAS
VDU1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 23032
MIM: 615146
HGNC: 20059
Ensembl: ENSG00000077254

Variants:

dbSNP: 23032
ClinVar: 23032
TCGA: ENSG00000077254
COSMIC: USP33

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000077254ENST00000357428Q8TEY7
ENSG00000077254ENST00000370792Q8TEY7
ENSG00000077254ENST00000370793Q8TEY7
ENSG00000077254ENST00000370794Q8TEY7
ENSG00000077254ENST00000481579H0YCV3
ENSG00000077254ENST00000524536E9PQP0
ENSG00000077254ENST00000524778E9PP47
ENSG00000077254ENST00000527390H0YD08
ENSG00000077254ENST00000530709E9PLK7

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
DeubiquitinationREACTOMER-HSA-5688426
Ub-specific processing proteasesREACTOMER-HSA-5689880

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
194241802009The deubiquitinases USP33 and USP20 coordinate beta2 adrenergic receptor recycling and resensitization.82
193631592009Beta-arrestin-dependent signaling and trafficking of 7-transmembrane receptors is reciprocally regulated by the deubiquitinase USP33 and the E3 ligase Mdm2.70
234860642013USP33 regulates centrosome biogenesis via deubiquitination of the centriolar protein CP110.59
128654082003Deubiquitination of type 2 iodothyronine deiodinase by von Hippel-Lindau protein-interacting deubiquitinating enzymes regulates thyroid hormone activation.52
197065392009Deubiquitinating enzyme USP33/VDU1 is required for Slit signaling in inhibiting breast cancer cell migration.34
240563012013The deubiquitylase USP33 discriminates between RALB functions in autophagy and innate immune response.34
278358982016Prognostic significance of USP33 in advanced colorectal cancer patients: new insights into β-arrestin-dependent ERK signaling.29
191185332009Human selenium binding protein-1 (hSP56) interacts with VDU1 in a selenium-dependent manner.27
196845882009Midline crossing and Slit responsiveness of commissural axons require USP33.20
252422632015USP33 mediates Slit-Robo signaling in inhibiting colorectal cancer cell migration.18

Citation

Dessen P

USP33 (ubiquitin specific peptidase 33)

Atlas Genet Cytogenet Oncol Haematol. 2009-10-01

Online version: http://atlasgeneticsoncology.org/gene/51144/usp33