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USP38 (ubiquitin specific peptidase 38)

Identity

Alias (NCBI)HP43.8KD
HGNC (Hugo) USP38
HGNC Alias symbKIAA1891
HP43.8KD
HGNC Previous nameubiquitin specific protease 38
LocusID (NCBI) 84640
Atlas_Id 75559
Location 4q31.21  [Link to chromosome band 4q31]
Location_base_pair Starts at 143184917 and ends at 143223874 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
C3 (19p13.3) / USP38 (4q31.21)GOSR1 (17q11.2) / USP38 (4q31.21)USP38 (4q31.21) / IL17F (6p12.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(4;6)(q31;p12) USP38/IL17F

External links

Nomenclature
HGNC (Hugo)USP38   20067
Cards
Entrez_Gene (NCBI)USP38  84640  ubiquitin specific peptidase 38
AliasesHP43.8KD
GeneCards (Weizmann)USP38
Ensembl hg19 (Hinxton)ENSG00000170185 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000170185 [Gene_View]  ENSG00000170185 [Sequence]  chr4:143184917-143223874 [Contig_View]  USP38 [Vega]
ICGC DataPortalENSG00000170185
TCGA cBioPortalUSP38
AceView (NCBI)USP38
Genatlas (Paris)USP38
WikiGenes84640
SOURCE (Princeton)USP38
Genetics Home Reference (NIH)USP38
Genomic and cartography
GoldenPath hg38 (UCSC)USP38  -     chr4:143184917-143223874 +  4q31.21   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)USP38  -     4q31.21   [Description]    (hg19-Feb_2009)
GoldenPathUSP38 - 4q31.21 [CytoView hg19]  USP38 - 4q31.21 [CytoView hg38]
ImmunoBaseENSG00000170185
genome Data Viewer NCBIUSP38 [Mapview hg19]  
OMIM618322   
Gene and transcription
Genbank (Entrez)AB067478 AF211481 AK057992 AK091712 AK093289
RefSeq transcript (Entrez)NM_001290325 NM_001290326 NM_032557
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)USP38
Alternative Splicing GalleryENSG00000170185
Gene ExpressionUSP38 [ NCBI-GEO ]   USP38 [ EBI - ARRAY_EXPRESS ]   USP38 [ SEEK ]   USP38 [ MEM ]
Gene Expression Viewer (FireBrowse)USP38 [ Firebrowse - Broad ]
GenevisibleExpression of USP38 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)84640
GTEX Portal (Tissue expression)USP38
Human Protein AtlasENSG00000170185-USP38 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8NB14   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8NB14  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8NB14
Splice isoforms : SwissVarQ8NB14
Catalytic activity : Enzyme3.4.19.12 [ Enzyme-Expasy ]   3.4.19.123.4.19.12 [ IntEnz-EBI ]   3.4.19.12 [ BRENDA ]   3.4.19.12 [ KEGG ]   [ MEROPS ]
PhosPhoSitePlusQ8NB14
Domaine pattern : Prosite (Expaxy)USP_1 (PS00972)    USP_2 (PS00973)    USP_3 (PS50235)   
Domains : Interpro (EBI)Papain-like_cys_pep_sf    Peptidase_C19_UCH    USP38    USP_CS    USP_dom   
Domain families : Pfam (Sanger)UCH (PF00443)   
Domain families : Pfam (NCBI)pfam00443   
Conserved Domain (NCBI)USP38
DMDM Disease mutations84640
Blocks (Seattle)USP38
PDB (RSDB)4RXX   
PDB Europe4RXX   
PDB (PDBSum)4RXX   
PDB (IMB)4RXX   
Structural Biology KnowledgeBase4RXX   
SCOP (Structural Classification of Proteins)4RXX   
CATH (Classification of proteins structures)4RXX   
SuperfamilyQ8NB14
Human Protein Atlas [tissue]ENSG00000170185-USP38 [tissue]
Peptide AtlasQ8NB14
HPRD15635
IPIIPI00168084   IPI00967144   IPI00966895   
Protein Interaction databases
DIP (DOE-UCLA)Q8NB14
IntAct (EBI)Q8NB14
FunCoupENSG00000170185
BioGRIDUSP38
STRING (EMBL)USP38
ZODIACUSP38
Ontologies - Pathways
QuickGOQ8NB14
Ontology : AmiGOcysteine-type endopeptidase activity  thiol-dependent ubiquitin-specific protease activity  thiol-dependent ubiquitin-specific protease activity  ubiquitin-dependent protein catabolic process  protein deubiquitination  protein deubiquitination  
Ontology : EGO-EBIcysteine-type endopeptidase activity  thiol-dependent ubiquitin-specific protease activity  thiol-dependent ubiquitin-specific protease activity  ubiquitin-dependent protein catabolic process  protein deubiquitination  protein deubiquitination  
NDEx NetworkUSP38
Atlas of Cancer Signalling NetworkUSP38
Wikipedia pathwaysUSP38
Orthology - Evolution
OrthoDB84640
GeneTree (enSembl)ENSG00000170185
Phylogenetic Trees/Animal Genes : TreeFamUSP38
HOGENOMQ8NB14
Homologs : HomoloGeneUSP38
Homology/Alignments : Family Browser (UCSC)USP38
Gene fusions - Rearrangements
Fusion : QuiverUSP38
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerUSP38 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)USP38
dbVarUSP38
ClinVarUSP38
1000_GenomesUSP38 
Exome Variant ServerUSP38
GNOMAD BrowserENSG00000170185
Varsome BrowserUSP38
Genetic variants : HAPMAP84640
Genomic Variants (DGV)USP38 [DGVbeta]
DECIPHERUSP38 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisUSP38 
Mutations
ICGC Data PortalUSP38 
TCGA Data PortalUSP38 
Broad Tumor PortalUSP38
OASIS PortalUSP38 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICUSP38  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DUSP38
Mutations and Diseases : HGMDUSP38
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch USP38
DgiDB (Drug Gene Interaction Database)USP38
DoCM (Curated mutations)USP38 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)USP38 (select a term)
intoGenUSP38
Cancer3DUSP38(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM618322   
Orphanet
DisGeNETUSP38
MedgenUSP38
Genetic Testing Registry USP38
NextProtQ8NB14 [Medical]
TSGene84640
GENETestsUSP38
Target ValidationUSP38
Huge Navigator USP38 [HugePedia]
snp3D : Map Gene to Disease84640
BioCentury BCIQUSP38
ClinGenUSP38
Clinical trials, drugs, therapy
Protein Interactions : CTD84640
Pharm GKB GenePA134880611
Clinical trialUSP38
Miscellaneous
canSAR (ICR)USP38 (select the gene name)
HarmonizomeUSP38
DataMed IndexUSP38
Probes
Litterature
PubMed18 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineUSP38
EVEXUSP38
GoPubMedUSP38
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Sat Aug 22 19:39:41 CEST 2020
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