USP39 (ubiquitin specific peptidase 39)

2014-05-01  

Identity

HGNC
USP39
LOCATION
2p11.2
LOCUSID
10713
ALIAS
65K,CGI-21,HSPC332,SAD1,SNRNP65
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 10713
MIM: 611594
HGNC: 20071
Ensembl: ENSG00000168883

Variants:

dbSNP: 10713
ClinVar: 10713
TCGA: ENSG00000168883
COSMIC: USP39

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000168883ENST00000323701Q53GS9
ENSG00000168883ENST00000409025B9A018
ENSG00000168883ENST00000409470Q53GS9
ENSG00000168883ENST00000409766Q53GS9
ENSG00000168883ENST00000442708C9J0X5
ENSG00000168883ENST00000448971C9JIU2
ENSG00000168883ENST00000450066Q53GS9
ENSG00000168883ENST00000458268F8WC91
ENSG00000168883ENST00000467885A0A087WW31
ENSG00000168883ENST00000613444A0A087X1B2

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
SpliceosomeKEGGko03040
SpliceosomeKEGGhsa03040
Spliceosome, U4/U6.U5 tri-snRNPKEGGhsa_M00354
Spliceosome, U4/U6.U5 tri-snRNPKEGGM00354
Gene ExpressionREACTOMER-HSA-74160
Processing of Capped Intron-Containing Pre-mRNAREACTOMER-HSA-72203
mRNA SplicingREACTOMER-HSA-72172
mRNA Splicing - Major PathwayREACTOMER-HSA-72163

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
187283972008Usp39 is essential for mitotic spindle checkpoint integrity and controls mRNA-levels of aurora B.32
241269782013Lentivirus-mediated inhibition of USP39 suppresses the growth of breast cancer cells in vitro.10
281541812017USP39 Deubiquitinase Is Essential for KRAS Oncogene-driven Cancer.10
260811922015USP39 promotes the growth of human hepatocellular carcinoma in vitro and in vivo.6
269598832016Overexpression of USP39 predicts poor prognosis and promotes tumorigenesis of prostate cancer via promoting EGFR mRNA maturation and transcription elongation.6
274563572016Knockdown of USP39 induces cell cycle arrest and apoptosis in melanoma.6
282599172017USP39 promotes colorectal cancer growth and metastasis through the Wnt/β-catenin pathway.6
284039002017Knockdown of ubiquitin-specific peptidase 39 inhibited the growth of osteosarcoma cells and induced apoptosis in vitro.6
282862702017USP39, a direct target of microRNA-133a, promotes progression of pancreatic cancer via the AKT pathway.5

Citation

Dessen P

USP39 (ubiquitin specific peptidase 39)

Atlas Genet Cytogenet Oncol Haematol. 2014-05-01

Online version: http://atlasgeneticsoncology.org/gene/53915/usp39