USP46 (ubiquitin specific peptidase 46)

2014-08-01  

Identity

HGNC
LOCATION
4q12
LOCUSID
ALIAS
-
FUSION GENES

Other Information

Locus ID:

NCBI: 64854
MIM: 612849
HGNC: 20075
Ensembl: ENSG00000109189

Variants:

dbSNP: 64854
ClinVar: 64854
TCGA: ENSG00000109189
COSMIC: USP46

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000109189ENST00000441222P62068
ENSG00000109189ENST00000451218H7BZK6
ENSG00000109189ENST00000503060D6R9Z4
ENSG00000109189ENST00000508499P62068
ENSG00000109189ENST00000512656D6RIX7
ENSG00000109189ENST00000514536D6R9Z4

Expression (GTEx)

0
5
10
15
20
25
30
35

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
190750142009UAF1 is a subunit of multiple deubiquitinating enzyme complexes.81
223915632013The deubiquitination enzyme USP46 functions as a tumor suppressor by controlling PHLPP-dependent attenuation of Akt signaling in colon cancer.33
192601412009Genome-wide association study of biochemical traits in Korcula Island, Croatia.30
258559802015The EBNA3 family of Epstein-Barr virus nuclear proteins associates with the USP46/USP12 deubiquitination complexes to regulate lymphoblastoid cell line growth.17
201110602010Association study of ubiquitin-specific peptidase 46 (USP46) with bipolar disorder and schizophrenia in a Japanese population.6
201110602010Association study of ubiquitin-specific peptidase 46 (USP46) with bipolar disorder and schizophrenia in a Japanese population.6
216639722011Possible association between ubiquitin-specific peptidase 46 gene and major depressive disorders in the Japanese population.5
304159512018The Deubiquitinase USP46 Is Essential for Proliferation and Tumor Growth of HPV-Transformed Cancers.3
315422322019Ubiquitin-specific peptidase 46 (USP46) suppresses renal cell carcinoma tumorigenesis through AKT pathway inactivation.0

Citation

Dessen P

USP46 (ubiquitin specific peptidase 46)

Atlas Genet Cytogenet Oncol Haematol. 2014-08-01

Online version: http://atlasgeneticsoncology.org/gene/54763/usp46