USP49 (ubiquitin specific peptidase 49)

2021-06-01  

Identity

HGNC
USP49
LOCATION
6p21.1
LOCUSID
25862
ALIAS
-

Other Information

Locus ID:

NCBI: 25862
HGNC: 20078
Ensembl: ENSG00000164663

Variants:

dbSNP: 25862
ClinVar: 25862
TCGA: ENSG00000164663
COSMIC: USP49

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000164663ENST00000373006Q70CQ1
ENSG00000164663ENST00000373010Q5T3E1
ENSG00000164663ENST00000394253Q70CQ1
ENSG00000164663ENST00000423567A6PVU3
ENSG00000164663ENST00000448078H7BZI7

Expression (GTEx)

0
5
10
15
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
DeubiquitinationREACTOMER-HSA-5688426
Ub-specific processing proteasesREACTOMER-HSA-5689880

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
238243262013USP49 deubiquitinates histone H2B and regulates cotranscriptional pre-mRNA splicing.38
283639422017USP49 negatively regulates tumorigenesis and chemoresistance through FKBP51-AKT signaling.23
297485822018USP49 participates in the DNA damage response by forming a positive feedback loop with p53.8
302464572019USP49 inhibits ischemia-reperfusion-induced cell viability suppression and apoptosis in human AC16 cardiomyocytes through DUSP1-JNK1/2 signaling.3
310019182019Ubiquitin specific peptidase 49 inhibits non-small cell lung cancer cell growth by suppressing PI3K/AKT signaling.1
313976742019USP49 potently stabilizes APOBEC3G protein by removing ubiquitin and inhibits HIV-1 replication.0

Citation

Dessen P

USP49 (ubiquitin specific peptidase 49)

Atlas Genet Cytogenet Oncol Haematol. 2021-06-01

Online version: http://atlasgeneticsoncology.org/gene/58369/usp49