USP5 (ubiquitin specific peptidase 5)

2003-11-01  

Identity

HGNC
USP5
LOCATION
12p13.31
LOCUSID
8078
ALIAS
ISOT
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 8078
MIM: 601447
HGNC: 12628
Ensembl: ENSG00000111667

Variants:

dbSNP: 8078
ClinVar: 8078
TCGA: ENSG00000111667
COSMIC: USP5

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000111667ENST00000229268P45974
ENSG00000111667ENST00000229268A0A140VJZ1
ENSG00000111667ENST00000389231P45974
ENSG00000111667ENST00000542087F5H571

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
DeubiquitinationREACTOMER-HSA-5688426
Ub-specific processing proteasesREACTOMER-HSA-5689880
Protein ubiquitinationREACTOMER-HSA-8852135
Synthesis of active ubiquitin: roles of E1 and E2 enzymesREACTOMER-HSA-8866652

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
165640122006The ubiquitin binding domain ZnF UBP recognizes the C-terminal diglycine motif of unanchored ubiquitin.130
190982882009Suppression of the deubiquitinating enzyme USP5 causes the accumulation of unanchored polyubiquitin and the activation of p53.69
219764122012PTBP1-dependent regulation of USP5 alternative RNA splicing plays a role in glioblastoma tumorigenesis.26
222833932012Two ZnF-UBP domains in isopeptidase T (USP5).18
289337842017Inhibition of the deubiquitinase USP5 leads to c-Maf protein degradation and myeloma cell apoptosis.17
244547622014Ubiquitin-specific protease 5 is required for the efficient repair of DNA double-strand breaks.13
288078302017USP5 promotes tumorigenesis and progression of pancreatic cancer by stabilizing FoxM1 protein.11
256419362015Ion mobility-mass spectrometry reveals conformational flexibility in the deubiquitinating enzyme USP5.9
295678552018Deubiquitylases USP5 and USP13 are recruited to and regulate heat-induced stress granules through their deubiquitylating activities.9
313004592019Genetic variations in A20 DUB domain provide a genetic link to citrullination and neutrophil extracellular traps in systemic lupus erythematosus.6

Citation

Dessen P

USP5 (ubiquitin specific peptidase 5)

Atlas Genet Cytogenet Oncol Haematol. 2003-11-01

Online version: http://atlasgeneticsoncology.org/gene/42772/usp5