Identity
HGNC
LOCATION
15q21.2
LOCUSID
ALIAS
HumORF8,PITA4,SPG59,UBPY
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 9101
MIM: 603158
HGNC: 12631
Ensembl: ENSG00000138592
Variants:
dbSNP: 9101
ClinVar: 9101
TCGA: ENSG00000138592
COSMIC: USP8
RNA/Proteins
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 37704159 | 2024 | Central role of ubiquitin-specific protease 8 in leptin signaling pathway in pulmonary arterial hypertension. | 0 |
| 38180476 | 2024 | USP8 prevents aberrant NF-κB and Nrf2 activation by counteracting ubiquitin signals from endosomes. | 1 |
| 38691659 | 2024 | A long-term prognosis study of human USP8-mutated ACTH-secreting pituitary neuroendocrine tumours. | 0 |
| 37704159 | 2024 | Central role of ubiquitin-specific protease 8 in leptin signaling pathway in pulmonary arterial hypertension. | 0 |
| 38180476 | 2024 | USP8 prevents aberrant NF-κB and Nrf2 activation by counteracting ubiquitin signals from endosomes. | 1 |
| 38691659 | 2024 | A long-term prognosis study of human USP8-mutated ACTH-secreting pituitary neuroendocrine tumours. | 0 |
| 37190052 | 2023 | USP8 Down-Regulation Promotes Parkin-Independent Mitophagy in the Drosophila Brain and in Human Neurons. | 0 |
| 37332045 | 2023 | piRNA-1742 promotes renal cell carcinoma malignancy by regulating USP8 stability through binding to hnRNPU and thereby inhibiting MUC12 ubiquitination. | 7 |
| 37639742 | 2023 | USP8 promotes gemcitabine resistance of pancreatic cancer via deubiquitinating and stabilizing Nrf2. | 3 |
| 37741774 | 2023 | USP8 targeted by Mir-874-3p promotes trophoblastic cell invasion by stabilizing the expression of ENaC on trophoblast membrane. | 0 |
| 37925320 | 2023 | Clinical Spectrum of USP8 Pathogenic Variants in Cushing's Disease. | 2 |
| 37981592 | 2023 | Polymorphic USP8 allele promotes Parkinson's disease by inducing the accumulation of α-synuclein through deubiquitination. | 0 |
| 37190052 | 2023 | USP8 Down-Regulation Promotes Parkin-Independent Mitophagy in the Drosophila Brain and in Human Neurons. | 0 |
| 37332045 | 2023 | piRNA-1742 promotes renal cell carcinoma malignancy by regulating USP8 stability through binding to hnRNPU and thereby inhibiting MUC12 ubiquitination. | 7 |
| 37639742 | 2023 | USP8 promotes gemcitabine resistance of pancreatic cancer via deubiquitinating and stabilizing Nrf2. | 3 |
Citation
Dessen P
USP8 (ubiquitin specific peptidase 8)
Atlas Genet Cytogenet Oncol Haematol. 2003-02-01
Online version: http://atlasgeneticsoncology.org/gene/42774/usp8
