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USP8 (ubiquitin specific peptidase 8)

Identity

Alias (NCBI)HumORF8
PITA4
SPG59
UBPY
HGNC (Hugo) USP8
HGNC Alias symbHumORF8
KIAA0055
UBPY
SPG59
HGNC Previous nameubiquitin specific protease 8
LocusID (NCBI) 9101
Atlas_Id 42774
Location 15q21.2  [Link to chromosome band 15q21]
Location_base_pair Starts at 50424405 and ends at 50514421 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
PXDNL (8q11.22) / USP8 (15q21.2)USP8 (15q21.2) / BDP1 (5q13.2)USP8 (15q21.2) / CCDC171 (9p22.3)
USP8 (15q21.2) / GALK2 (15q21.1)USP8 (15q21.2) / SLC27A2 (15q21.2)USP8 (15q21.2) / TRPM7 (15q21.2)
PXDNL 8q11.22 / USP8 15q21.2USP8 15q21.2 / BDP1 5q13.2USP8 15q21.2 C9orf93
USP8 15q21.2 / SLC27A2 15q21.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)USP8   12631
Cards
Entrez_Gene (NCBI)USP8    ubiquitin specific peptidase 8
AliasesHumORF8; PITA4; SPG59; UBPY
GeneCards (Weizmann)USP8
Ensembl hg19 (Hinxton)ENSG00000138592 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000138592 [Gene_View]  ENSG00000138592 [Sequence]  chr15:50424405-50514421 [Contig_View]  USP8 [Vega]
ICGC DataPortalENSG00000138592
TCGA cBioPortalUSP8
AceView (NCBI)USP8
Genatlas (Paris)USP8
SOURCE (Princeton)USP8
Genetics Home Reference (NIH)USP8
Genomic and cartography
GoldenPath hg38 (UCSC)USP8  -     chr15:50424405-50514421 +  15q21.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)USP8  -     15q21.2   [Description]    (hg19-Feb_2009)
GoldenPathUSP8 - 15q21.2 [CytoView hg19]  USP8 - 15q21.2 [CytoView hg38]
ImmunoBaseENSG00000138592
genome Data Viewer NCBIUSP8 [Mapview hg19]  
OMIM219090   603158   
Gene and transcription
Genbank (Entrez)AA399951 AA399952 AA773713 AI276208 AK091775
RefSeq transcript (Entrez)NM_001128610 NM_001128611 NM_001283049 NM_005154
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)USP8
Alternative Splicing GalleryENSG00000138592
Gene ExpressionUSP8 [ NCBI-GEO ]   USP8 [ EBI - ARRAY_EXPRESS ]   USP8 [ SEEK ]   USP8 [ MEM ]
Gene Expression Viewer (FireBrowse)USP8 [ Firebrowse - Broad ]
GenevisibleExpression of USP8 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)9101
GTEX Portal (Tissue expression)USP8
Human Protein AtlasENSG00000138592-USP8 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP40818   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP40818  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP40818
Splice isoforms : SwissVarP40818
PhosPhoSitePlusP40818
Domaine pattern : Prosite (Expaxy)RHODANESE_3 (PS50206)    USP_1 (PS00972)    USP_2 (PS00973)    USP_3 (PS50235)   
Domains : Interpro (EBI)Papain-like_cys_pep_sf    Peptidase_C19_UCH    Rhodanese-like_dom    Rhodanese-like_dom_sf    USP8_dimer    USP_CS    USP_dom   
Domain families : Pfam (Sanger)Rhodanese (PF00581)    UCH (PF00443)    USP8_dimer (PF08969)   
Domain families : Pfam (NCBI)pfam00581    pfam00443    pfam08969   
Conserved Domain (NCBI)USP8
Blocks (Seattle)USP8
PDB (RSDB)1WHB    2A9U    2GFO    2GWF    3N3K    6F09   
PDB Europe1WHB    2A9U    2GFO    2GWF    3N3K    6F09   
PDB (PDBSum)1WHB    2A9U    2GFO    2GWF    3N3K    6F09   
PDB (IMB)1WHB    2A9U    2GFO    2GWF    3N3K    6F09   
Structural Biology KnowledgeBase1WHB    2A9U    2GFO    2GWF    3N3K    6F09   
SCOP (Structural Classification of Proteins)1WHB    2A9U    2GFO    2GWF    3N3K    6F09   
CATH (Classification of proteins structures)1WHB    2A9U    2GFO    2GWF    3N3K    6F09   
SuperfamilyP40818
Human Protein Atlas [tissue]ENSG00000138592-USP8 [tissue]
Peptide AtlasP40818
HPRD04405
IPIIPI00030915   IPI00941811   IPI00872245   IPI00952731   
Protein Interaction databases
DIP (DOE-UCLA)P40818
IntAct (EBI)P40818
BioGRIDUSP8
STRING (EMBL)USP8
ZODIACUSP8
Ontologies - Pathways
QuickGOP40818
Ontology : AmiGOmitotic cytokinesis  cysteine-type endopeptidase activity  thiol-dependent ubiquitin-specific protease activity  thiol-dependent ubiquitin-specific protease activity  thiol-dependent ubiquitin-specific protease activity  protein binding  nucleus  cytoplasm  early endosome  cytosol  cytosol  cytosol  ubiquitin-dependent protein catabolic process  endosome organization  endosome organization  Ras protein signal transduction  postsynaptic density  protein deubiquitination  protein deubiquitination  SH3 domain binding  protein phosphopantetheinylation  extrinsic component of plasma membrane  extrinsic component of plasma membrane  midbody  midbody  extrinsic component of endosome membrane  regulation of protein stability  regulation of protein localization  dendritic spine  cadherin binding  protein K63-linked deubiquitination  protein K63-linked deubiquitination  protein K48-linked deubiquitination  protein K48-linked deubiquitination  cellular response to dexamethasone stimulus  positive regulation of canonical Wnt signaling pathway  glutamatergic synapse  regulation of protein catabolic process at postsynapse, modulating synaptic transmission  cellular response to nerve growth factor stimulus  
Ontology : EGO-EBImitotic cytokinesis  cysteine-type endopeptidase activity  thiol-dependent ubiquitin-specific protease activity  thiol-dependent ubiquitin-specific protease activity  thiol-dependent ubiquitin-specific protease activity  protein binding  nucleus  cytoplasm  early endosome  cytosol  cytosol  cytosol  ubiquitin-dependent protein catabolic process  endosome organization  endosome organization  Ras protein signal transduction  postsynaptic density  protein deubiquitination  protein deubiquitination  SH3 domain binding  protein phosphopantetheinylation  extrinsic component of plasma membrane  extrinsic component of plasma membrane  midbody  midbody  extrinsic component of endosome membrane  regulation of protein stability  regulation of protein localization  dendritic spine  cadherin binding  protein K63-linked deubiquitination  protein K63-linked deubiquitination  protein K48-linked deubiquitination  protein K48-linked deubiquitination  cellular response to dexamethasone stimulus  positive regulation of canonical Wnt signaling pathway  glutamatergic synapse  regulation of protein catabolic process at postsynapse, modulating synaptic transmission  cellular response to nerve growth factor stimulus  
Pathways : KEGGEndocytosis   
NDEx NetworkUSP8
Atlas of Cancer Signalling NetworkUSP8
Wikipedia pathwaysUSP8
Orthology - Evolution
OrthoDB9101
GeneTree (enSembl)ENSG00000138592
Phylogenetic Trees/Animal Genes : TreeFamUSP8
HOGENOMP40818
Homologs : HomoloGeneUSP8
Homology/Alignments : Family Browser (UCSC)USP8
Gene fusions - Rearrangements
Fusion : MitelmanPXDNL/USP8 [8q11.22/15q21.2]  
Fusion : MitelmanUSP8/BDP1 [15q21.2/5q13.2]  
Fusion : MitelmanUSP8/CCDC171 [15q21.2/9p22.3]  
Fusion : MitelmanUSP8/SLC27A2 [15q21.2/15q21.2]  
Fusion PortalPXDNL 8q11.22 USP8 15q21.2 SKCM
Fusion PortalUSP8 15q21.2 BDP1 5q13.2 SKCM
Fusion PortalUSP8 15q21.2 C9orf93 BRCA
Fusion PortalUSP8 15q21.2 SLC27A2 15q21.2 BRCA
Fusion : QuiverUSP8
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerUSP8 [hg38]
dbVarUSP8
ClinVarUSP8
MonarchUSP8
1000_GenomesUSP8 
Exome Variant ServerUSP8
GNOMAD BrowserENSG00000138592
Varsome BrowserUSP8
Genomic Variants (DGV)USP8 [DGVbeta]
DECIPHERUSP8 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisUSP8 
Mutations
ICGC Data PortalUSP8 
TCGA Data PortalUSP8 
Broad Tumor PortalUSP8
OASIS PortalUSP8 [ Somatic mutations - Copy number]
Cancer Gene: CensusUSP8 
Somatic Mutations in Cancer : COSMICUSP8  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DUSP8
Mutations and Diseases : HGMDUSP8
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch USP8
DgiDB (Drug Gene Interaction Database)USP8
DoCM (Curated mutations)USP8 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)USP8 (select a term)
intoGenUSP8
Cancer3DUSP8(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM219090    603158   
Orphanet22830    12827   
DisGeNETUSP8
MedgenUSP8
Genetic Testing Registry USP8
NextProtP40818 [Medical]
GENETestsUSP8
Target ValidationUSP8
Huge Navigator USP8 [HugePedia]
ClinGenUSP8
Clinical trials, drugs, therapy
MyCancerGenomeUSP8
Protein Interactions : CTD
Pharm GKB GenePA37256
PharosP40818
Clinical trialUSP8
Miscellaneous
canSAR (ICR)USP8 (select the gene name)
HarmonizomeUSP8
DataMed IndexUSP8
Probes
Litterature
PubMed139 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXUSP8
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Thu Mar 25 19:52:23 CET 2021
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