USP9X (ubiquitin specific peptidase 9 X-linked)

2009-09-01  

Identity

HGNC
LOCATION
Xp11.4
LOCUSID
ALIAS
DFFRX,FAF,FAM,MRX99,MRXS99F
FUSION GENES

Other Information

Locus ID:

NCBI: 8239
MIM: 300072
HGNC: 12632
Ensembl: ENSG00000124486

Variants:

dbSNP: 8239
ClinVar: 8239
TCGA: ENSG00000124486
COSMIC: USP9X

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000124486ENST00000324545Q93008
ENSG00000124486ENST00000378308Q93008

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45

Pathways

PathwaySourceExternal ID
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
Amyloid fiber formationREACTOMER-HSA-977225
Signal TransductionREACTOMER-HSA-162582
Signaling by TGF-beta Receptor ComplexREACTOMER-HSA-170834
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimerREACTOMER-HSA-2173793
Downregulation of SMAD2/3:SMAD4 transcriptional activityREACTOMER-HSA-2173795
Gene ExpressionREACTOMER-HSA-74160
Generic Transcription PathwayREACTOMER-HSA-212436
DeubiquitinationREACTOMER-HSA-5688426
Ub-specific processing proteasesREACTOMER-HSA-5689880
Protein ubiquitinationREACTOMER-HSA-8852135
Synthesis of active ubiquitin: roles of E1 and E2 enzymesREACTOMER-HSA-8866652

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
200236292010Deubiquitinase USP9X stabilizes MCL1 and promotes tumour cell survival.275
191358942009FAM/USP9x, a deubiquitinating enzyme essential for TGFbeta signaling, controls Smad4 monoubiquitination.206
226996212012The deubiquitinase USP9X suppresses pancreatic ductal adenocarcinoma.139
182547242008Control of AMPK-related kinases by USP9X and atypical Lys(29)/Lys(33)-linked polyubiquitin chains.89
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
211731552011Zymophagy, a novel selective autophagy pathway mediated by VMP1-USP9x-p62, prevents pancreatic cell death.79
170383272006The ubiquitin ligase itch is auto-ubiquitylated in vivo and in vitro but is protected from degradation by interacting with the deubiquitylating enzyme FAM/USP9X.62
220657552011α-Synuclein fate is determined by USP9X-regulated monoubiquitination.60
212480632011Bcr-Abl ubiquitination and Usp9x inhibition block kinase signaling and promote CML cell apoptosis.51
231849372013Deubiquitinase FAM/USP9X interacts with the E3 ubiquitin ligase SMURF1 protein and protects it from ligase activity-dependent self-degradation.46

Citation

Dessen P

USP9X (ubiquitin specific peptidase 9 X-linked)

Atlas Genet Cytogenet Oncol Haematol. 2009-09-01

Online version: http://atlasgeneticsoncology.org/gene/51119/usp9x