UTF1 (undifferentiated embryonic cell transcription factor 1)

2010-10-01  

Identity

HGNC
UTF1
LOCATION
10q26.3
LOCUSID
8433
ALIAS
-

Other Information

Locus ID:

NCBI: 8433
MIM: 604130
HGNC: 12634
Ensembl: ENSG00000171794

Variants:

dbSNP: 8433
ClinVar: 8433
TCGA: ENSG00000171794
COSMIC: UTF1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000171794ENST00000304477Q5T230

Expression (GTEx)

0
5
10
15
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

References

Pubmed IDYearTitleCitations
189839622008Two supporting factors greatly improve the efficiency of human iPSC generation.181
182812442008Presumed pluripotency markers UTF-1 and REX-1 are expressed in human adult testes and germ cell neoplasms.31
231016262012Regulation of pluripotency and self- renewal of ESCs through epigenetic-threshold modulation and mRNA pruning.31
193935922009Characterization of human UTF1, a chromatin-associated protein with repressor activity expressed in pluripotent cells.10
228800872012Aberrant promoter methylation and expression of UTF1 during cervical carcinogenesis.9
235365772013Undifferentiated embryonic cell transcription factor-1 (UTF1) inhibits the growth of cervical cancer cells by transactivating p27Kip1.9
208556422010Expression of UTF1 in primary and metastatic testicular germ cell tumors.4
214469392011Embryonic stem cell factors undifferentiated transcription factor-1 (UFT-1) and reduced expression protein-1 (REX-1) are widely expressed in human skin and may be involved in cutaneous differentiation but not in stem cell fate determination.2
202188972010Functional characterization of single-nucleotide polymorphisms in the human undifferentiated embryonic-cell transcription factor 1 gene.0
246147042014The embryonic stem cell factor UTF1 serves as a reliable diagnostic marker for germinomas.0

Citation

Dessen P

UTF1 (undifferentiated embryonic cell transcription factor 1)

Atlas Genet Cytogenet Oncol Haematol. 2010-10-01

Online version: http://atlasgeneticsoncology.org/gene/51719/utf1