UTS2R (urotensin 2 receptor)

2008-01-01 Affiliation

Identity

HGNC

UTS2R

LOCATION

17q25.3

LOCUSID

2837

ALIAS

GPR14,UR-2-R,UTR,UTR2

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 2837
MIM: 600896
HGNC: 4468
Ensembl: ENSG00000181408

Variants:

dbSNP: 2837
ClinVar: 2837
TCGA: ENSG00000181408
COSMIC: UTS2R

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000181408	ENST00000313135	Q9UKP6

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Neuroactive ligand-receptor interaction	KEGG	ko04080
Neuroactive ligand-receptor interaction	KEGG	hsa04080
Signal Transduction	REACTOME	R-HSA-162582
Signaling by GPCR	REACTOME	R-HSA-372790
GPCR ligand binding	REACTOME	R-HSA-500792
Class A/1 (Rhodopsin-like receptors)	REACTOME	R-HSA-373076
Peptide ligand-binding receptors	REACTOME	R-HSA-375276
GPCR downstream signaling	REACTOME	R-HSA-388396
G alpha (q) signalling events	REACTOME	R-HSA-416476
Gastrin-CREB signalling pathway via PKC and MAPK	REACTOME	R-HSA-881907

References

Pubmed ID	Year	Title	Citations
15306183	2004	Increased expression of urotensin II and its cognate receptor GPR14 in atherosclerotic lesions of the human aorta.	17
17617581	2007	Urotensin II is a new chemotactic factor for UT receptor-expressing monocytes.	15
21080343	2011	Urotensin II receptor predicts the clinical outcome of prostate cancer patients and is involved in the regulation of motility of prostate adenocarcinoma cells.	12
24893613	2014	Urotensin II receptor determines prognosis of bladder cancer regulating cell motility/invasion.	12
27715446	2016	Chemotactic G protein-coupled receptors control cell migration by repressing autophagosome biogenesis.	11
16597476	2006	Haplotypes in the urotensin II gene and urotensin II receptor gene are associated with insulin resistance and impaired glucose tolerance.	10
15476949	2004	Genetic variations at urotensin II and urotensin II receptor genes and risk of type 2 diabetes mellitus in Japanese.	9
24372535	2014	Urotensin-II receptor is over-expressed in colon cancer cell lines and in colon carcinoma in humans.	9
15752584	2005	Characterization of functional urotensin II receptors in human skeletal muscle myoblasts: comparison with angiotensin II receptors.	7
26381851	2015	Urotensin II receptor on preoperative biopsy is associated with upstaging and upgrading in prostate cancer.	7

Citation

Dessen P

UTS2R (urotensin 2 receptor)

Atlas Genet Cytogenet Oncol Haematol. 2008-01-01

Online version: http://atlasgeneticsoncology.org/gene/49974/uts2r