UVRAG (UV radiation resistance associated)

2003-02-01  

Identity

HGNC
LOCATION
11q13.5
LOCUSID
ALIAS
DHTX,VPS38,p63
FUSION GENES

Other Information

Locus ID:

NCBI: 7405
MIM: 602493
HGNC: 12640
Ensembl: ENSG00000198382

Variants:

dbSNP: 7405
ClinVar: 7405
TCGA: ENSG00000198382
COSMIC: UVRAG

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000198382ENST00000356136Q9P2Y5
ENSG00000198382ENST00000525183H0YDD1
ENSG00000198382ENST00000528264E9PK00
ENSG00000198382ENST00000528420E9PR71
ENSG00000198382ENST00000531818Q9P2Y5
ENSG00000198382ENST00000532130Q9P2Y5
ENSG00000198382ENST00000533454Q9P2Y5

Expression (GTEx)

0
5
10
15
20
25
30
35
40

Pathways

PathwaySourceExternal ID
Autophagy - animalKEGGko04140
Autophagy - animalKEGGhsa04140
Cellular responses to stressREACTOMER-HSA-2262752
MacroautophagyREACTOMER-HSA-1632852

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
188430522008Beclin 1 forms two distinct phosphatidylinositol 3-kinase complexes with mammalian Atg14 and UVRAG.457
185528352008Beclin1-binding UVRAG targets the class C Vps complex to coordinate autophagosome maturation and endocytic trafficking.294
206431232010A phosphatidylinositol 3-kinase class III sub-complex containing VPS15, VPS34, Beclin 1, UVRAG and BIF-1 regulates cytokinesis and degradative endocytic traffic.79
223143582012Imperfect interface of Beclin1 coiled-coil domain regulates homodimer and heterodimer formation with Atg14L and UVRAG.71
184952052008Frameshift mutation of UVRAG, an autophagy-related gene, in gastric carcinomas with microsatellite instability.64
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
255331872015mTORC1 phosphorylates UVRAG to negatively regulate autophagosome and endosome maturation.61
225428402012A dual role for UVRAG in maintaining chromosomal stability independent of autophagy.43
258071082015HCV induces the expression of Rubicon and UVRAG to temporally regulate the maturation of autophagosomes and viral replication.40
186413902008Bcl-xL and UVRAG cause a monomer-dimer switch in Beclin1.38

Citation

Dessen P

UVRAG (UV radiation resistance associated)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/42778/uvrag