VAMP8 (vesicle associated membrane protein 8)

2014-08-01  

Identity

HGNC
LOCATION
2p11.2
LOCUSID
ALIAS
EDB,VAMP-8
FUSION GENES

Other Information

Locus ID:

NCBI: 8673
MIM: 603177
HGNC: 12647
Ensembl: ENSG00000118640

Variants:

dbSNP: 8673
ClinVar: 8673
TCGA: ENSG00000118640
COSMIC: VAMP8

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000118640ENST00000263864Q9BV40
ENSG00000118640ENST00000409760B8ZZT4
ENSG00000118640ENST00000432071C9JXZ5

Expression (GTEx)

0
50
100
150
200
250
300

Pathways

PathwaySourceExternal ID
SNARE interactions in vesicular transportKEGGko04130
Autophagy - animalKEGGko04140
SNARE interactions in vesicular transportKEGGhsa04130
Autophagy - animalKEGGhsa04140
Platelet activationKEGGhsa04611
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Class I MHC mediated antigen processing & presentationREACTOMER-HSA-983169
Antigen processing-Cross presentationREACTOMER-HSA-1236975
ER-Phagosome pathwayREACTOMER-HSA-1236974
Innate Immune SystemREACTOMER-HSA-168249
Vesicle-mediated transportREACTOMER-HSA-5653656
Membrane TraffickingREACTOMER-HSA-199991
trans-Golgi Network Vesicle BuddingREACTOMER-HSA-199992
Clathrin derived vesicle buddingREACTOMER-HSA-421837
Golgi Associated Vesicle BiogenesisREACTOMER-HSA-432722
Lysosome Vesicle BiogenesisREACTOMER-HSA-432720
Clathrin-mediated endocytosisREACTOMER-HSA-8856828
Cargo recognition for clathrin-mediated endocytosisREACTOMER-HSA-8856825
Neutrophil degranulationREACTOMER-HSA-6798695

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
200898382010Combinational soluble N-ethylmaleimide-sensitive factor attachment protein receptor proteins VAMP8 and Vti1b mediate fusion of antimicrobial and canonical autophagosomes with lysosomes.68
179751192008Association of gene variants with incident myocardial infarction in the Cardiovascular Health Study.65
199438782010VAMP8/endobrevin is overexpressed in hyperreactive human platelets: suggested role for platelet microRNA.55
121305302002Vesicle-associated membrane protein 3 (VAMP-3) and VAMP-8 are present in human platelets and are required for granule secretion.47
180735812007Five common gene variants identify elevated genetic risk for coronary heart disease.43
214869542011Endocytic membrane fusion and buckling-induced microtubule severing mediate cell abscission.38
182539312008Vesicle associated membrane protein (VAMP)-7 and VAMP-8, but not VAMP-2 or VAMP-3, are required for activation-induced degranulation of mature human mast cells.35
256481482015Starvation-induced MTMR13 and RAB21 activity regulates VAMP8 to promote autophagosome-lysosome fusion.28
166908742006Gene variants of VAMP8 and HNRPUL1 are associated with early-onset myocardial infarction.27

Citation

Dessen P

VAMP8 (vesicle associated membrane protein 8)

Atlas Genet Cytogenet Oncol Haematol. 2014-08-01

Online version: http://atlasgeneticsoncology.org/gene/54765/vamp8