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VARS1 (valyl-tRNA synthetase 1)

Identity

Alias (NCBI)G7A
NDMSCA
VARS
VARS2
HGNC (Hugo) VARS1
HGNC Alias namevaline tRNA ligase 1, cytoplasmic
HGNC Previous nameVARS2
HGNC Previous namevalyl-tRNA synthetase 2
LocusID (NCBI) 7407
Atlas_Id 75584
Location 6p21.33  [Link to chromosome band 6p21]
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute



Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 2 ]
  TAP2/VARS (6p21)
t(6;17)(p21;q23) VARS/VMP1


External links

Nomenclature
HGNC (Hugo)VARS1   12651
Cards
Entrez_Gene (NCBI)VARS1  7407  valyl-tRNA synthetase 1
AliasesG7A; NDMSCA; VARS; VARS2
GeneCards (Weizmann)VARS1
Ensembl hg19 (Hinxton)ENSG00000204394 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000204394 [Gene_View]  ENSG00000204394 [Sequence]  - [Contig_View]  VARS1 [Vega]
ICGC DataPortalENSG00000204394
TCGA cBioPortalVARS1
AceView (NCBI)VARS1
Genatlas (Paris)VARS1
WikiGenes7407
SOURCE (Princeton)VARS1
Genetics Home Reference (NIH)VARS1
Genomic and cartography
GoldenPath hg38 (UCSC)VARS1  -  
GoldenPath hg19 (UCSC)VARS1  -  
GoldenPathVARS1 - [CytoView hg19]  VARS1 - [CytoView hg38]
ImmunoBaseENSG00000204394
genome Data Viewer NCBIVARS1 [Mapview hg19]  
OMIM192150   617802   
Gene and transcription
Genbank (Entrez)AK300033 AK302762 BC012808 CX167000 CX781162
RefSeq transcript (Entrez)NM_006295
RefSeq genomic (Entrez)NC_000006 NG_028229 NT_113891 NT_167244 NT_167245 NT_167247 NT_167248 NT_167249
Consensus coding sequences : CCDS (NCBI)VARS1
Alternative Splicing GalleryENSG00000204394
Gene ExpressionVARS1 [ NCBI-GEO ]   VARS1 [ EBI - ARRAY_EXPRESS ]   VARS1 [ SEEK ]   VARS1 [ MEM ]
Gene Expression Viewer (FireBrowse)VARS1 [ Firebrowse - Broad ]
GenevisibleExpression of VARS1 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)7407
GTEX Portal (Tissue expression)VARS1
Human Protein AtlasENSG00000204394-VARS1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP26640   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP26640  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP26640
Splice isoforms : SwissVarP26640
Catalytic activity : Enzyme6.1.1.9 [ Enzyme-Expasy ]   6.1.1.96.1.1.9 [ IntEnz-EBI ]   6.1.1.9 [ BRENDA ]   6.1.1.9 [ KEGG ]   [ MEROPS ]
PhosPhoSitePlusP26640
Domaine pattern : Prosite (Expaxy)AA_TRNA_LIGASE_I (PS00178)    GST_CTER (PS50405)   
Domains : Interpro (EBI)aa-tRNA-synth_I_CS    aa-tRNA-synth_Ia    Anticodon_Ia_Val    Glutathione-S-Trfase_C-like    Glutathione-S-Trfase_C_sf    GST_C    M/V/L/I-tRNA-synth_anticd-bd    Rossmann-like_a/b/a_fold    tRNAsynth_Ia_anticodon-bd    Val-tRNA_synth_C_sf    Val/Leu/Ile-tRNA-synth_edit    Valyl-tRNA_ligase   
Domain families : Pfam (Sanger)Anticodon_1 (PF08264)    GST_C (PF00043)    tRNA-synt_1 (PF00133)   
Domain families : Pfam (NCBI)pfam08264    pfam00043    pfam00133   
Conserved Domain (NCBI)VARS1
DMDM Disease mutations7407
Blocks (Seattle)VARS1
SuperfamilyP26640
Human Protein Atlas [tissue]ENSG00000204394-VARS1 [tissue]
Peptide AtlasP26640
HPRD10362
IPIIPI00000873   IPI00908612   IPI00893487   IPI00646425   IPI00793323   IPI00788898   IPI00893918   IPI00893211   IPI00893333   
Protein Interaction databases
DIP (DOE-UCLA)P26640
IntAct (EBI)P26640
FunCoupENSG00000204394
BioGRIDVARS1
STRING (EMBL)VARS1
ZODIACVARS1
Ontologies - Pathways
QuickGOP26640
Ontology : AmiGOaminoacyl-tRNA editing activity  valine-tRNA ligase activity  valine-tRNA ligase activity  valine-tRNA ligase activity  protein binding  ATP binding  cytosol  cytosol  cytosol  tRNA aminoacylation for protein translation  valyl-tRNA aminoacylation  aminoacyl-tRNA metabolism involved in translational fidelity  
Ontology : EGO-EBIaminoacyl-tRNA editing activity  valine-tRNA ligase activity  valine-tRNA ligase activity  valine-tRNA ligase activity  protein binding  ATP binding  cytosol  cytosol  cytosol  tRNA aminoacylation for protein translation  valyl-tRNA aminoacylation  aminoacyl-tRNA metabolism involved in translational fidelity  
Pathways : KEGGValine, leucine and isoleucine biosynthesis    Aminoacyl-tRNA biosynthesis   
NDEx NetworkVARS1
Atlas of Cancer Signalling NetworkVARS1
Wikipedia pathwaysVARS1
Orthology - Evolution
OrthoDB7407
GeneTree (enSembl)ENSG00000204394
Phylogenetic Trees/Animal Genes : TreeFamVARS1
HOGENOMP26640
Homologs : HomoloGeneVARS1
Homology/Alignments : Family Browser (UCSC)VARS1
Gene fusions - Rearrangements
Fusion : QuiverVARS1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerVARS1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)VARS1
dbVarVARS1
ClinVarVARS1
1000_GenomesVARS1 
Exome Variant ServerVARS1
GNOMAD BrowserENSG00000204394
Varsome BrowserVARS1
Genetic variants : HAPMAP7407
Genomic Variants (DGV)VARS1 [DGVbeta]
DECIPHERVARS1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisVARS1 
Mutations
ICGC Data PortalVARS1 
TCGA Data PortalVARS1 
Broad Tumor PortalVARS1
OASIS PortalVARS1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICVARS1  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DVARS1
Mutations and Diseases : HGMDVARS1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch VARS1
DgiDB (Drug Gene Interaction Database)VARS1
DoCM (Curated mutations)VARS1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)VARS1 (select a term)
intoGenVARS1
Cancer3DVARS1(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM192150    617802   
Orphanet
DisGeNETVARS1
MedgenVARS1
Genetic Testing Registry VARS1
NextProtP26640 [Medical]
TSGene7407
GENETestsVARS1
Target ValidationVARS1
Huge Navigator VARS1 [HugePedia]
snp3D : Map Gene to Disease7407
BioCentury BCIQVARS1
ClinGenVARS1
Clinical trials, drugs, therapy
Protein Interactions : CTD7407
Pharm GKB GenePA37275
Clinical trialVARS1
Miscellaneous
canSAR (ICR)VARS1 (select the gene name)
HarmonizomeVARS1
DataMed IndexVARS1
Probes
Litterature
PubMed65 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineVARS1
EVEXVARS1
GoPubMedVARS1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Sat Aug 22 19:04:49 CEST 2020

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