VASP (vasodilator stimulated phosphoprotein)

2007-02-01 Affiliation

Identity

HGNC

VASP

LOCATION

19q13.32

LOCUSID

7408

ALIAS

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 7408
MIM: 601703
HGNC: 12652
Ensembl: ENSG00000125753

Variants:

dbSNP: 7408
ClinVar: 7408
TCGA: ENSG00000125753
COSMIC: VASP

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000125753	ENST00000245932	P50552
ENSG00000125753	ENST00000245932	A0A024R0V4
ENSG00000125753	ENST00000586014	K7ENL7
ENSG00000125753	ENST00000588482	K7EM16
ENSG00000125753	ENST00000589627	K7ENR7
ENSG00000125753	ENST00000590603	K7EQD0
ENSG00000125753	ENST00000592139	K7EIG8

Expression (GTEx)

100

150

200

250

300

350

400

450

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Focal adhesion	KEGG	ko04510
Tight junction	KEGG	ko04530
Leukocyte transendothelial migration	KEGG	ko04670
Focal adhesion	KEGG	hsa04510
Tight junction	KEGG	hsa04530
Leukocyte transendothelial migration	KEGG	hsa04670
Fc gamma R-mediated phagocytosis	KEGG	ko04666
Fc gamma R-mediated phagocytosis	KEGG	hsa04666
Rap1 signaling pathway	KEGG	hsa04015
Rap1 signaling pathway	KEGG	ko04015
Platelet activation	KEGG	hsa04611
cGMP-PKG signaling pathway	KEGG	hsa04022
cGMP-PKG signaling pathway	KEGG	ko04022
Immune System	REACTOME	R-HSA-168256
Adaptive Immune System	REACTOME	R-HSA-1280218
TCR signaling	REACTOME	R-HSA-202403
Generation of second messenger molecules	REACTOME	R-HSA-202433
Cell-Cell communication	REACTOME	R-HSA-1500931
Cell junction organization	REACTOME	R-HSA-446728
Cell-extracellular matrix interactions	REACTOME	R-HSA-446353
Developmental Biology	REACTOME	R-HSA-1266738
Axon guidance	REACTOME	R-HSA-422475
Signaling by Robo receptor	REACTOME	R-HSA-376176

Protein levels (Protein atlas)

Not detected

Low

Medium

High

PharmGKB

Entity ID	Name	Type	Evidence	Association	PK	PD	PMIDs
PA444552	Hypertension	Disease	ClinicalAnnotation, VariantAnnotation	associated		PD
PA449899	hydrochlorothiazide	Chemical	ClinicalAnnotation, VariantAnnotation	associated		PD

References

Pubmed ID	Year	Title	Citations
21041447	2010	VASP is a processive actin polymerase that requires monomeric actin for barbed end association.	110
17914456	2007	Structural basis for the recruitment of profilin-actin complexes during filament elongation by Ena/VASP.	91
18923426	2008	Clustering of VASP actively drives processive, WH2 domain-mediated actin filament elongation.	82
15158464	2004	Myosin X transports Mena/VASP to the tip of filopodia.	73
19825941	2009	Differential VASP phosphorylation controls remodeling of the actin cytoskeleton.	52
15569942	2004	The VASP tetramerization domain is a right-handed coiled coil based on a 15-residue repeat.	50
12805219	2003	A role for VASP in RhoA-Diaphanous signalling to actin dynamics and SRF activity.	44
19115233	2009	Loss of profilin-1 expression enhances breast cancer cell motility by Ena/VASP proteins.	43
15634270	2005	Flow cytometric analysis of intraplatelet VASP phosphorylation for the detection of clopidogrel resistance in patients with ischemic cardiovascular diseases.	40
17082196	2007	AMP-activated protein kinase impairs endothelial actin cytoskeleton assembly by phosphorylating vasodilator-stimulated phosphoprotein.	40

Citation

Dessen P

VASP (vasodilator stimulated phosphoprotein)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46391/vasp