VDAC3 (voltage dependent anion channel 3)

2015-06-01  

Identity

HGNC
LOCATION
8p11.21
LOCUSID
ALIAS
HD-VDAC3,VDAC-3
FUSION GENES

Other Information

Locus ID:

NCBI: 7419
MIM: 610029
HGNC: 12674
Ensembl: ENSG00000078668

Variants:

dbSNP: 7419
ClinVar: 7419
TCGA: ENSG00000078668
COSMIC: VDAC3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000078668ENST00000022615Q9Y277
ENSG00000078668ENST00000518495E5RFL1
ENSG00000078668ENST00000518563E5RK27
ENSG00000078668ENST00000520115E5RHZ6
ENSG00000078668ENST00000521158Q9Y277
ENSG00000078668ENST00000522010E5RHE1
ENSG00000078668ENST00000522069E5RJN6
ENSG00000078668ENST00000522572E5RFP6

Expression (GTEx)

0
50
100
150
200
250
300

Pathways

PathwaySourceExternal ID
Calcium signaling pathwayKEGGko04020
Huntington's diseaseKEGGko05016
Calcium signaling pathwayKEGGhsa04020
Parkinson's diseaseKEGGhsa05012
Huntington's diseaseKEGGhsa05016
NOD-like receptor signaling pathwayKEGGko04621
NOD-like receptor signaling pathwayKEGGhsa04621
HTLV-I infectionKEGGko05166
HTLV-I infectionKEGGhsa05166
Viral carcinogenesisKEGGhsa05203
Viral carcinogenesisKEGGko05203
Hepatitis BKEGGhsa05161
cGMP-PKG signaling pathwayKEGGhsa04022
cGMP-PKG signaling pathwayKEGGko04022
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
DeubiquitinationREACTOMER-HSA-5688426
Ub-specific processing proteasesREACTOMER-HSA-5689880
FerroptosisKEGGko04216
FerroptosisKEGGhsa04216

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
230604382012Voltage-dependent anion channels (VDACs) recruit Parkin to defective mitochondria to promote mitochondrial autophagy.63
201388212010Characterization of human VDAC isoforms: a peculiar function for VDAC3?50
176830362007Human spermatozoa contain multiple targets for protein S-nitrosylation: an alternative mechanism of the modulation of sperm function by nitric oxide?43
253410362014Mcl-1 promotes lung cancer cell migration by directly interacting with VDAC to increase mitochondrial Ca2+ uptake and reactive oxygen species generation.36
147392832004Voltage-dependent anion-selective channels VDAC2 and VDAC3 are abundant proteins in bovine outer dense fibers, a cytoskeletal component of the sperm flagellum.21
269470582016Role of cysteines in mammalian VDAC isoforms' function.19
204344462010Swapping of the N-terminus of VDAC1 with VDAC3 restores full activity of the channel and confers anti-aging features to the cell.18
233884542013VDAC3 and Mps1 negatively regulate ciliogenesis.18
251713212014Recombinant human voltage dependent anion selective channel isoform 3 (hVDAC3) forms pores with a very small conductance.18
264077252015VDAC3 gating is activated by suppression of disulfide-bond formation between the N-terminal region and the bottom of the pore.18

Citation

Dessen P

VDAC3 (voltage dependent anion channel 3)

Atlas Genet Cytogenet Oncol Haematol. 2015-06-01

Online version: http://atlasgeneticsoncology.org/gene/55291/vdac3