VEPH1 (ventricular zone expressed PH domain containing 1)

2015-10-01  

Identity

HGNC
VEPH1
LOCATION
3q25.31
LOCUSID
79674
ALIAS
MELT,VEPH
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 79674
MIM: 609594
HGNC: 25735
Ensembl: ENSG00000197415

Variants:

dbSNP: 79674
ClinVar: 79674
TCGA: ENSG00000197415
COSMIC: VEPH1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000197415ENST00000362010Q14D04
ENSG00000197415ENST00000392832Q14D04
ENSG00000197415ENST00000392833Q14D04
ENSG00000197415ENST00000461299C9J4U8
ENSG00000197415ENST00000468233Q14D04
ENSG00000197415ENST00000473907F8WBQ3
ENSG00000197415ENST00000475050F8WBD3
ENSG00000197415ENST00000479987C9IZY4
ENSG00000197415ENST00000487753C9JRT0
ENSG00000197415ENST00000489602C9J379
ENSG00000197415ENST00000494677Q14D04
ENSG00000197415ENST00000537559Q14D04

Expression (GTEx)

0
5
10
15
20
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
202374962010New genetic associations detected in a host response study to hepatitis B vaccine.27
206280862010Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.11
260399942015Human ortholog of Drosophila Melted impedes SMAD2 release from TGF-β receptor I to inhibit TGF-β signaling.6
283018742017VEPH1 expression decreases vascularisation in ovarian cancer xenografts and inhibits VEGFA and IL8 expression through inhibition of AKT activation.2
316142062020Increased androgen receptor levels and signaling in ovarian cancer cells by VEPH1 associated with suppression of SMAD3 and AKT activation.1

Citation

Dessen P

VEPH1 (ventricular zone expressed PH domain containing 1)

Atlas Genet Cytogenet Oncol Haematol. 2015-10-01

Online version: http://atlasgeneticsoncology.org/gene/55447/veph1