VGF (VGF nerve growth factor inducible)

2007-11-01  

Identity

HGNC
LOCATION
7q22.1
LOCUSID
ALIAS
SCG7,SgVII

Other Information

Locus ID:

NCBI: 7425
MIM: 602186
HGNC: 12684
Ensembl: ENSG00000128564

Variants:

dbSNP: 7425
ClinVar: 7425
TCGA: ENSG00000128564
COSMIC: VGF

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000128564ENST00000249330O15240
ENSG00000128564ENST00000445482O15240
ENSG00000128564ENST00000611537Q05BJ3

Expression (GTEx)

0
50
100
150

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
195982352009Genes related to sex steroids, neural growth, and social-emotional behavior are associated with autistic traits, empathy, and Asperger syndrome.92
164815982006Identification of potential CSF biomarkers in ALS.64
176845002008Replication of linkage on chromosome 7q22 and association of the regional Reelin gene with working memory in schizophrenia families.33
201648312010The expression of VGF is reduced in leukocytes of depressed patients and it is restored by effective antidepressant treatment.24
216216082011VGF: an inducible gene product, precursor of a diverse array of neuro-endocrine peptides and tissue-specific disease biomarkers.24
184323102008Vgf is a novel biomarker associated with muscle weakness in amyotrophic lateral sclerosis (ALS), with a potential role in disease pathogenesis.23
206311662010The neuropeptide VGF is reduced in human bipolar postmortem brain and contributes to some of the behavioral and molecular effects of lithium.21
211515732010An inducer of VGF protects cells against ER stress-induced cell death and prolongs survival in the mutant SOD1 animal models of familial ALS.21
240862492013Association of promoter methylation of VGF and PGP9.5 with ovarian cancer progression.18
174400142007Peptide products of the neurotrophin-inducible gene vgf are produced in human neuroendocrine cells from early development and increase in hyperplasia and neoplasia.16

Citation

Dessen P

VGF (VGF nerve growth factor inducible)

Atlas Genet Cytogenet Oncol Haematol. 2007-11-01

Online version: http://atlasgeneticsoncology.org/gene/49821/vgf