VGLL4 (vestigial like family member 4)

2011-12-01 Affiliation

Identity

HGNC

VGLL4

LOCATION

3p25.3

LOCUSID

9686

ALIAS

VGL-4

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 9686
MIM: 618692
HGNC: 28966
Ensembl: ENSG00000144560

Variants:

dbSNP: 9686
ClinVar: 9686
TCGA: ENSG00000144560
COSMIC: VGLL4

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000144560	ENST00000273038	A0A075B6E4
ENSG00000144560	ENST00000413604	G5E9M9
ENSG00000144560	ENST00000417206	F8W708
ENSG00000144560	ENST00000417466	F8WBN7
ENSG00000144560	ENST00000418000	E7EQU6
ENSG00000144560	ENST00000419541	E7EUJ2
ENSG00000144560	ENST00000424529	Q14135
ENSG00000144560	ENST00000424709	C9JBN2
ENSG00000144560	ENST00000426568	A0A0A6YYI5
ENSG00000144560	ENST00000430365	G5E9M7
ENSG00000144560	ENST00000437722	C9JX59
ENSG00000144560	ENST00000445411	E7EWF5
ENSG00000144560	ENST00000451674	Q14135
ENSG00000144560	ENST00000458499	E7ERW0
ENSG00000144560	ENST00000623028	A0A096LP98
ENSG00000144560	ENST00000638314	A0A1W2PQQ9

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
24525233	2014	A peptide mimicking VGLL4 function acts as a YAP antagonist therapy against gastric cancer.	155
24458094	2014	VGLL4 functions as a new tumor suppressor in lung cancer by negatively regulating the YAP-TEAD transcriptional complex.	82
19240061	2009	Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling.	75
20379614	2010	Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.	62
15140898	2004	Vgl-4, a novel member of the vestigial-like family of transcription cofactors, regulates alpha1-adrenergic activation of gene expression in cardiac myocytes.	39
15140898	2004	Vgl-4, a novel member of the vestigial-like family of transcription cofactors, regulates alpha1-adrenergic activation of gene expression in cardiac myocytes.	39
15140898	2004	Vgl-4, a novel member of the vestigial-like family of transcription cofactors, regulates alpha1-adrenergic activation of gene expression in cardiac myocytes.	39
20702774	2010	IRF2BP2 is a skeletal and cardiac muscle-enriched ischemia-inducible activator of VEGFA expression.	28
28051067	2017	VGLL4 targets a TCF4-TEAD4 complex to coregulate Wnt and Hippo signalling in colorectal cancer.	28
25701461	2015	VGLL4 inhibits EMT in part through suppressing Wnt/β-catenin signaling pathway in gastric cancer.	20

Citation

Dessen P

VGLL4 (vestigial like family member 4)

Atlas Genet Cytogenet Oncol Haematol. 2011-12-01

Online version: http://atlasgeneticsoncology.org/gene/52512/vgll4