VIPR1 (vasoactive intestinal peptide receptor 1)

2003-11-01  

Identity

HGNC
LOCATION
3p22.1
LOCUSID
ALIAS
HVR1,II,PACAP-R-2,PACAP-R2,RDC1,V1RG,VAPC1,VIP-R-1,VIPR,VIRG,VPAC1,VPAC1R,VPCAP1R
FUSION GENES

Other Information

Locus ID:

NCBI: 7433
MIM: 192321
HGNC: 12694
Ensembl: ENSG00000114812

Variants:

dbSNP: 7433
ClinVar: 7433
TCGA: ENSG00000114812
COSMIC: VIPR1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000114812ENST00000325123P32241
ENSG00000114812ENST00000433647P32241
ENSG00000114812ENST00000433647A0A024R2N2
ENSG00000114812ENST00000436487F2Z2U6
ENSG00000114812ENST00000438259P32241
ENSG00000114812ENST00000439731C9JDT8
ENSG00000114812ENST00000439910F2Z2U6
ENSG00000114812ENST00000443646F2Z2U6
ENSG00000114812ENST00000446673F2Z2U6
ENSG00000114812ENST00000450274C9JH33
ENSG00000114812ENST00000543411P32241

Expression (GTEx)

0
50
100
150
200

Pathways

PathwaySourceExternal ID
Neuroactive ligand-receptor interactionKEGGko04080
Neuroactive ligand-receptor interactionKEGGhsa04080
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (s) signalling eventsREACTOMER-HSA-418555

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
195982352009Genes related to sex steroids, neural growth, and social-emotional behavior are associated with autistic traits, empathy, and Asperger syndrome.92
190860532009Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment.34
170771782006Altered expression of vasoactive intestinal peptide receptors in T lymphocytes and aberrant Th1 immunity in multiple sclerosis.23
165203742006Peptide agonist docking in the N-terminal ectodomain of a class II G protein-coupled receptor, the VPAC1 receptor. Photoaffinity, NMR, and molecular modeling.22
183833792008Genetic association of vasoactive intestinal peptide receptor with rheumatoid arthritis: altered expression and signal in immune cells.22
206917432010Nuclear localization of vasoactive intestinal peptide (VIP) receptors in human breast cancer.21
119301712002Distribution of mRNA for VIP and PACAP receptors in human cerebral arteries and cranial ganglia.18
178852052008The vasoactive intestinal peptide (VIP) alpha-Helix up to C terminus interacts with the N-terminal ectodomain of the human VIP/Pituitary adenylate cyclase-activating peptide 1 receptor: photoaffinity, molecular modeling, and dynamics.17
181743662008VIP differentially activates beta2 integrins, CR1, and matrix metalloproteinase-9 in human monocytes through cAMP/PKA, EPAC, and PI-3K signaling pathways via VIP receptor type 1 and FPRL1.17
126901182003Identification of cytoplasmic domains of hVPAC1 receptor required for activation of adenylyl cyclase. Crucial role of two charged amino acids strictly conserved in class II G protein-coupled receptors.16

Citation

Dessen P

VIPR1 (vasoactive intestinal peptide receptor 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-11-01

Online version: http://atlasgeneticsoncology.org/gene/42792/vipr1