VNN2 (vanin 2)

2018-12-01  

Identity

HGNC
VNN2
LOCATION
6q23.2
LOCUSID
8875
ALIAS
FOAP-4,GPI-80

Other Information

Locus ID:

NCBI: 8875
MIM: 603571
HGNC: 12706
Ensembl: ENSG00000112303

Variants:

dbSNP: 8875
ClinVar: 8875
TCGA: ENSG00000112303
COSMIC: VNN2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000112303ENST00000326499O95498
ENSG00000112303ENST00000392389J3QT03
ENSG00000112303ENST00000418593J3KQ55
ENSG00000112303ENST00000422400J3KQQ7
ENSG00000112303ENST00000524919E9PL76
ENSG00000112303ENST00000525270O95498
ENSG00000112303ENST00000525289O95498
ENSG00000112303ENST00000525674O95498
ENSG00000112303ENST00000528801E9PLK5
ENSG00000112303ENST00000530536E9PRD9
ENSG00000112303ENST00000531279E9PQ75
ENSG00000112303ENST00000532012E9PK31
ENSG00000112303ENST00000532053O95498
ENSG00000112303ENST00000533835B4DQB2

Expression (GTEx)

0
100
200
300
400
500
600
700
800
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Pantothenate and CoA biosynthesisKEGGko00770
Pantothenate and CoA biosynthesisKEGGhsa00770
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
Post-translational modification: synthesis of GPI-anchored proteinsREACTOMER-HSA-163125
MetabolismREACTOMER-HSA-1430728
Metabolism of vitamins and cofactorsREACTOMER-HSA-196854
Metabolism of water-soluble vitamins and cofactorsREACTOMER-HSA-196849
Vitamin B5 (pantothenate) metabolismREACTOMER-HSA-199220

References

Pubmed IDYearTitleCitations
254651142015GPI-80 defines self-renewal ability in hematopoietic stem cells during human development.17
180951542008Use of expression data and the CGEMS genome-wide breast cancer association study to identify genes that may modify risk in BRCA1/2 mutation carriers.9
147485122003GPI-80, a beta2 integrin associated glycosylphosphatidylinositol-anchored protein, concentrates on pseudopodia without association with beta2 integrin during neutrophil migration.7
127498492003Expression of GPI-80, a beta2-integrin-associated glycosylphosphatidylinositol-anchored protein, requires neutrophil differentiation with dimethyl sulfoxide in HL-60 cells.4
127770632003Localization of GPI-80, a beta2-integrin-associated glycosylphosphatidyl-inositol anchored protein, on strongly CD14-positive human monocytes.4
129674802003Glycosylphosphatidyl inositol-anchored protein (GPI-80) gene expression is correlated with human thymoma stage.4
175432842007Structural divergence of GPI-80 in activated human neutrophils.3
300669492018MicroRNA‑106a regulates the proliferation and invasion of human osteosarcoma cells by targeting VNN2.3
275699962016The pattern of GPI-80 expression is a useful marker for unusual myeloid maturation in peripheral blood.1
317762982019GPI-80 as a Useful Index for Myeloid Cell Heterogeneity and a Potential Prognostic Biomarker for Metastatic Renal Cell Carcinoma.0

Citation

Dessen P

VNN2 (vanin 2)

Atlas Genet Cytogenet Oncol Haematol. 2018-12-01

Online version: http://atlasgeneticsoncology.org/gene/57785/vnn2