VPREB1 (V-set pre-B cell surrogate light chain 1)

2003-05-01 Affiliation

Identity

HGNC

VPREB1

LOCATION

22q11.22

LOCUSID

7441

ALIAS

CD179a,IGI,IGVPB,VPREB

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 7441
MIM: 605141
HGNC: 12709
Ensembl: ENSG00000169575
IMGT/GENE-DB:

Variants:

dbSNP: 7441
ClinVar: 7441
TCGA: ENSG00000169575
COSMIC: VPREB1

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000169575	ENST00000302273	F8W8C9
ENSG00000169575	ENST00000403807	P12018

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Hemostasis	REACTOME	R-HSA-109582
Cell surface interactions at the vascular wall	REACTOME	R-HSA-202733

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
20237496	2010	New genetic associations detected in a host response study to hepatitis B vaccine.	27
16818733	2006	Clustering of pre-B cell integrins induces galectin-1-dependent pre-B cell receptor relocalization and activation.	22
11994467	2002	The human V-preB promoter is a target for coordinated activation by early B cell factor and E47.	12
23881307	2014	VPREB1 deletions occur independent of lambda light chain rearrangement in childhood acute lymphoblastic leukemia.	8
21144590	2011	The potential role of VPREB1 gene copy number variation in susceptibility to rheumatoid arthritis.	5
27611867	2016	The Expression Pattern of the Pre-B Cell Receptor Components Correlates with Cellular Stage and Clinical Outcome in Acute Lymphoblastic Leukemia.	5

Citation

Dessen P

VPREB1 (V-set pre-B cell surrogate light chain 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-05-01

Online version: http://atlasgeneticsoncology.org/gene/42794/vpreb1