Identity
HGNC
LOCATION
22q11.22
LOCUSID
ALIAS
CD179a,IGI,IGVPB,VPREB
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 7441
MIM: 605141
HGNC: 12709
Ensembl: ENSG00000169575
IMGT/GENE-DB:
Variants:
dbSNP: 7441
ClinVar: 7441
TCGA: ENSG00000169575
COSMIC: VPREB1
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000169575 | ENST00000302273 | F8W8C9 |
| ENSG00000169575 | ENST00000403807 | P12018 |
Expression (GTEx)
Pathways
| Pathway | Source | External ID |
|---|---|---|
| Hemostasis | REACTOME | R-HSA-109582 |
| Cell surface interactions at the vascular wall | REACTOME | R-HSA-202733 |
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 35398858 | 2022 | Mutational Analysis of the VPREB1 Gene of Pre-BCR Complex in a Cohort of Sporadic Pediatric Patients With B-Cell Acute Lymphoblastic Leukemia. | 0 |
| 35398858 | 2022 | Mutational Analysis of the VPREB1 Gene of Pre-BCR Complex in a Cohort of Sporadic Pediatric Patients With B-Cell Acute Lymphoblastic Leukemia. | 0 |
| 33418558 | 2021 | CRISPR/Cas9 mediated knock-out of VPREB1 gene induces a cytotoxic effect in myeloma cells. | 4 |
| 33418558 | 2021 | CRISPR/Cas9 mediated knock-out of VPREB1 gene induces a cytotoxic effect in myeloma cells. | 4 |
| 33101545 | 2020 | Association of VPREB1 Gene Copy Number Variation and Rheumatoid Arthritis Susceptibility. | 2 |
| 33101545 | 2020 | Association of VPREB1 Gene Copy Number Variation and Rheumatoid Arthritis Susceptibility. | 2 |
| 27611867 | 2016 | The Expression Pattern of the Pre-B Cell Receptor Components Correlates with Cellular Stage and Clinical Outcome in Acute Lymphoblastic Leukemia. | 18 |
| 27611867 | 2016 | The Expression Pattern of the Pre-B Cell Receptor Components Correlates with Cellular Stage and Clinical Outcome in Acute Lymphoblastic Leukemia. | 18 |
| 23881307 | 2014 | VPREB1 deletions occur independent of lambda light chain rearrangement in childhood acute lymphoblastic leukemia. | 13 |
| 23881307 | 2014 | VPREB1 deletions occur independent of lambda light chain rearrangement in childhood acute lymphoblastic leukemia. | 13 |
| 21144590 | 2011 | The potential role of VPREB1 gene copy number variation in susceptibility to rheumatoid arthritis. | 6 |
| 21144590 | 2011 | The potential role of VPREB1 gene copy number variation in susceptibility to rheumatoid arthritis. | 6 |
| 20237496 | 2010 | New genetic associations detected in a host response study to hepatitis B vaccine. | 37 |
| 20237496 | 2010 | New genetic associations detected in a host response study to hepatitis B vaccine. | 37 |
| 16818733 | 2006 | Clustering of pre-B cell integrins induces galectin-1-dependent pre-B cell receptor relocalization and activation. | 32 |
Citation
Dessen P
VPREB1 (V-set pre-B cell surrogate light chain 1)
Atlas Genet Cytogenet Oncol Haematol. 2003-05-01
Online version: http://atlasgeneticsoncology.org/gene/42794/vpreb1
