VSIG4 (V-set and immunoglobulin domain containing 4)

2014-09-01  

Identity

HGNC
LOCATION
Xq12
LOCUSID
ALIAS
CRIg,Z39IG
FUSION GENES

Other Information

Locus ID:

NCBI: 11326
MIM: 300353
HGNC: 17032
Ensembl: ENSG00000155659

Variants:

dbSNP: 11326
ClinVar: 11326
TCGA: ENSG00000155659
COSMIC: VSIG4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000155659ENST00000374737Q9Y279
ENSG00000155659ENST00000412866Q9Y279
ENSG00000155659ENST00000427538H7C062
ENSG00000155659ENST00000455586Q9Y279
ENSG00000155659ENST00000651578A0A494C0F5

Expression (GTEx)

0
50
100
150

Pathways

PathwaySourceExternal ID
Complement and coagulation cascadesKEGGko04610
Complement and coagulation cascadesKEGGhsa04610

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
165300402006CRIg: a macrophage complement receptor required for phagocytosis of circulating pathogens.151
170511502006Structure of C3b in complex with CRIg gives insights into regulation of complement activation.84
170165622006VSIG4, a B7 family-related protein, is a negative regulator of T cell activation.59
203991482010Down-regulation of Z39Ig on macrophages by IFN-gamma in patients with chronic HBV infection.11
243493252013Evaluation of current and new biomarkers in severe preeclampsia: a microarray approach reveals the VSIG4 gene as a potential blood biomarker.9
168828752006Z39Ig is expressed on macrophages and may mediate inflammatory reactions in arthritis and atherosclerosis.8
248629662014VSIG4 expression on macrophages facilitates lung cancer development.8
256877552015Protein kinase cα regulates the expression of complement receptor Ig in human monocyte-derived macrophages.7
251141772014A novel CRIg-targeted complement inhibitor protects cells from complement damage.6
280052672017Human gingiva transcriptome during wound healing.6

Citation

Dessen P

VSIG4 (V-set and immunoglobulin domain containing 4)

Atlas Genet Cytogenet Oncol Haematol. 2014-09-01

Online version: http://atlasgeneticsoncology.org/gene/54897/vsig4